Gene Symbol: sys-1
Description: SYmmetrical Sister cell hermaphrodite gonad defect
Alias: SYmmetrical Sister cell hermaphrodite gonad defect
Species: Caenorhabditis elegans

Top Publications

  1. King R, Maiden S, Hawkins N, Kidd A, Kimble J, Hardin J, et al. The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway. Dev Biol. 2009;328:234-44 pubmed publisher
    ..These results indicate that either the DIX or DEP domain of DSH-2 is capable of activating the Wnt/beta-catenin asymmetry pathway and regulating anterior-posterior fate decisions required for proper morphogenesis. ..
  2. Miskowski J, Li Y, Kimble J. The sys-1 gene and sexual dimorphism during gonadogenesis in Caenorhabditis elegans. Dev Biol. 2001;230:61-73 pubmed
    ..We conclude that the primary role of sys-1 is to establish the shape and polarity of the hermaphrodite gonad. ..
  3. Lam N, Chesney M, Kimble J. Wnt signaling and CEH-22/tinman/Nkx2.5 specify a stem cell niche in C. elegans. Curr Biol. 2006;16:287-95 pubmed
    ..5 homeodomain transcription factor is a key regulator of DTC specification. We speculate that these conserved molecular regulators of the DTC niche in nematodes may provide insight into specification of stem cell niches more broadly. ..
  4. Chesney M, Lam N, Morgan D, Phillips B, Kimble J. C. elegans HLH-2/E/Daughterless controls key regulatory cells during gonadogenesis. Dev Biol. 2009;331:14-25 pubmed publisher
    ..We conclude that HLH-2 functions in both sexes to promote leader cell specification and DTC niche function. ..
  5. Vora S, Phillips B. Centrosome-Associated Degradation Limits β-Catenin Inheritance by Daughter Cells after Asymmetric Division. Curr Biol. 2015;25:1005-16 pubmed publisher
    ..Based on our observations of centrosomal SYS-1 dynamics, we discuss the possibility that the centrosome may coordinate various cell-cycle-dependent processes by synchronizing mitosis and protein regulation. ..
  6. Tilmann C, Kimble J. Cyclin D regulation of a sexually dimorphic asymmetric cell division. Dev Cell. 2005;9:489-99 pubmed
    ..We propose that cyclin D and other canonical regulators of the G1/S transition coordinate key regulators of axis formation and sex determination with cell cycle progression to achieve the sexually dimorphic SGP asymmetric division. ..
  7. Miller R, Portman D. The Wnt/beta-catenin asymmetry pathway patterns the atonal ortholog lin-32 to diversify cell fate in a Caenorhabditis elegans sensory lineage. J Neurosci. 2011;31:13281-91 pubmed publisher
    ..Moreover, they reveal a central role for the Wnt/?-catenin asymmetry pathway in patterning neural and glial fates in a simple sensory lineage. ..
  8. Tian C, Shi H, Colledge C, Stern M, Waterston R, Liu J. The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm. Development. 2011;138:1033-43 pubmed publisher
    ..elegans M lineage suggests a possible more general link between Hox-PBC factors and SoxC proteins in regulating cell proliferation. ..
  9. Huang S, Shetty P, Robertson S, Lin R. Binary cell fate specification during C. elegans embryogenesis driven by reiterated reciprocal asymmetry of TCF POP-1 and its coactivator beta-catenin SYS-1. Development. 2007;134:2685-95 pubmed
    ..We propose that two genetic pathways, one increasing SYS-1 and the other decreasing POP-1 levels, robustly elevate the SYS-1-to-POP-1 ratio in the posterior cell, thereby driving A-P differential cell fates. ..

More Information


  1. Liu J, Phillips B, Amaya M, Kimble J, Xu W. The C. elegans SYS-1 protein is a bona fide beta-catenin. Dev Cell. 2008;14:751-61 pubmed publisher
    ..We conclude that the SYS-1 protein belongs to the beta-catenin family and suggest that additional divergent beta-catenins await discovery. ..
  2. Gleason J, Eisenmann D. Wnt signaling controls the stem cell-like asymmetric division of the epithelial seam cells during C. elegans larval development. Dev Biol. 2010;348:58-66 pubmed publisher
    ..elegans larval development, and that Wnt pathway regulation of stem cell-like behavior is conserved in nematodes. ..
  3. Zacharias A, Walton T, Preston E, Murray J. Quantitative Differences in Nuclear β-catenin and TCF Pattern Embryonic Cells in C. elegans. PLoS Genet. 2015;11:e1005585 pubmed publisher
  4. Asahina M, Valenta T, Silhankova M, Korinek V, Jindra M. Crosstalk between a nuclear receptor and beta-catenin signaling decides cell fates in the C. elegans somatic gonad. Dev Cell. 2006;11:203-11 pubmed
    ..This balance relies on direct crossregulation between NHR-25 and the distinct beta-catenin proteins WRM-1 and SYS-1. The nuclear receptor-beta-catenin interaction may be an ancient mechanism of cell-fate decision. ..
  5. Kidd A, Miskowski J, Siegfried K, Sawa H, Kimble J. A beta-catenin identified by functional rather than sequence criteria and its role in Wnt/MAPK signaling. Cell. 2005;121:761-72 pubmed
    ..We discuss the idea that a similar pathway may be employed broadly in animal development. ..
  6. Siegfried K, Kidd A, Chesney M, Kimble J. The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad. Genetics. 2004;166:171-86 pubmed
    ..We suggest that sys-3 is a new key gene in this pathway and that gon-14, gon-15, and gon-16 may cooperate with POP-1 and SYS-1 at multiple stages of gonad development. ..
  7. Phillips B, Kidd A, King R, Hardin J, Kimble J. Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2007;104:3231-6 pubmed
    ..We suggest a two-pronged pathway for control of SYS-1:POP-1, which can robustly accomplish differential gene expression in daughters of an asymmetric cell division. ..
  8. Yang X, Huang S, Lo M, Mizumoto K, Sawa H, Xu W, et al. Distinct and mutually inhibitory binding by two divergent ?-catenins coordinates TCF levels and activity in C. elegans. Development. 2011;138:4255-65 pubmed publisher
    ..These studies could provide novel insights into cancers arising from aberrant Wnt activation. ..