Gene Symbol: sur-6
Description: Serine/threonine-protein phosphatase 2A regulatory subunit sur-6
Alias: Serine/threonine-protein phosphatase 2A regulatory subunit sur-6
Species: Caenorhabditis elegans
Kao G, Tuck S, Baillie D, Sundaram M. C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites. Development. 2004;131:755-65 pubmed
..In addition to their roles in Ras signaling, SUR-6/PR55 and LET-92/PP2A-C cooperate to control mitotic progression during early embryogenesis. ..
Song M, Liu Y, Anderson D, Jahng W, O Connell K. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011;20:563-71 pubmed publisher
..Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation. ..
Sieburth D, Sundaram M, Howard R, Han M. A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction. Genes Dev. 1999;13:2562-9 pubmed
..Double mutant analysis suggests that sur-6 PP2A-B acts downstream or in parallel to ras, but likely upstream of raf, and functions with ksr-1 in a common pathway to positively regulate Ras signaling. ..
Eastburn D, Han M. A gain-of-function allele of cbp-1, the Caenorhabditis elegans ortholog of the mammalian CBP/p300 gene, causes an increase in histone acetyltransferase activity and antagonism of activated Ras. Mol Cell Biol. 2005;25:9427-34 pubmed
..To our knowledge, this is the only such HAT activity mutation isolated in a CBP/p300 family protein, and this mutation may define a negative role of the HAT activity in antagonizing Ras function in a specific developmental event. ..
Jiu Y, Hasygar K, Tang L, Liu Y, Holmberg C, B rglin T, et al
. par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans. G3 (Bethesda). 2014;4:173-83 pubmed publisher