sur 2


Gene Symbol: sur 2
Description: Mediator of RNA polymerase II transcription subunit 23
Alias: Mediator of RNA polymerase II transcription subunit 23
Species: Caenorhabditis elegans

Top Publications

  1. Howard R, Sundaram M. C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component. Genes Dev. 2002;16:1815-27 pubmed
    ..Further studies of eor-1 and eor-2 may provide insight into the roles of PLZF in normal development and leukemogenesis. ..
  2. Yoda A, Kouike H, Okano H, Sawa H. Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans. Development. 2005;132:1885-93 pubmed
    ..These results suggest that LET-19 and DPY-22 in the Mediator complex repress the transcription of Wnt target genes. ..
  3. Seah A, Sternberg P. The roles of EGF and Wnt signaling during patterning of the C. elegans Bgamma/delta Equivalence Group. BMC Dev Biol. 2009;9:74 pubmed publisher
    ..Our results suggest that dbl-1/dpp is not required for VPC and P12 specification, highlighting another difference among these EGF-dependent equivalence groups. ..
  4. Nicholas H, Hodgkin J. The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans. Curr Biol. 2004;14:1256-61 pubmed
    ..elegans from severe constipation, which would otherwise arrest development and cause sterility. Involvement in pathogen defense represents a new role for ERK MAP kinase signaling in this organism. ..
  5. Shaye D, Greenwald I. LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans. Development. 2005;132:5081-92 pubmed
  6. Mahalak K, Jama A, Billups S, Dawes A, Chamberlin H. Differing roles for sur-2/MED23 in C. elegans and C. briggsae vulval development. Dev Genes Evol. 2017;227:213-218 pubmed publisher
    ..elegans but not in C. briggsae. Our results provide genetic evidence for the differing requirements for EGF signaling in the two species. ..