srgp-1

Summary

Gene Symbol: srgp-1
Description: Slit-Robo GAP homolog
Alias: Slit-Robo GAP homolog
Species: Caenorhabditis elegans

Top Publications

  1. Zaidel Bar R, Joyce M, Lynch A, Witte K, Audhya A, Hardin J. The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis. J Cell Biol. 2010;191:761-9 pubmed publisher
    ..These studies establish a new role for this conserved protein family in modulating cell-cell adhesion. ..
  2. Neukomm L, Frei A, Cabello J, Kinchen J, Zaidel Bar R, Ma Z, et al. Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans. Nat Cell Biol. 2011;13:79-86 pubmed publisher
    ..We propose that C. elegans uses the engulfment machinery as part of a primitive, but evolutionarily conserved, survey mechanism that identifies and removes unfit cells within a tissue. ..
  3. Callaci S, Morrison K, Shao X, Schuh A, Wang Y, Yates J, et al. Phosphoregulation of the C. elegans cadherin-catenin complex. Biochem J. 2015;472:339-52 pubmed publisher
    ..Collectively, our findings support a model in which distinct phosphorylation events contribute to rapid CCC assembly and disassembly, both of which are essential for morphogenetic rearrangements during development. ..