Gene Symbol: src-1
Description: Tyrosine protein-kinase src-1
Alias: Tyrosine protein-kinase src-1
Species: Caenorhabditis elegans
Products:     src-1

Top Publications

  1. Bei Y, Hogan J, Berkowitz L, Soto M, Rocheleau C, Pang K, et al. SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos. Dev Cell. 2002;3:113-25 pubmed
    ..Our findings suggest that Wnt and Src signaling function in parallel to control developmental outcomes within a single responding cell. ..
  2. Maduro M, Hill R, Heid P, Newman Smith E, Zhu J, Priess J, et al. Genetic redundancy in endoderm specification within the genus Caenorhabditis. Dev Biol. 2005;284:509-22 pubmed
    ..briggsae end genes also function redundantly to specify endoderm. We propose that duplicated end genes have been maintained over long periods of evolution, owing in part to their synergistic function. ..
  3. Itoh B, Hirose T, Takata N, Nishiwaki K, Koga M, Ohshima Y, et al. SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans. Development. 2005;132:5161-72 pubmed
    ..These findings show that SRC-1 functions in responding to various extracellular guidance cues that direct the cell migration via disparate signaling pathways in different cell types. ..
  4. Seirin Lee S. Positioning of polarity formation by extracellular signaling during asymmetric cell division. J Theor Biol. 2016;400:52-64 pubmed publisher
    ..I show that a positive correlation between SRC-1 and the on-rate of PAR-2 is the essential mechanism underlying polarity reversal, providing a mathematical basis for the orientation of cell polarity patterns. ..
  5. Hirose T, Koga M, Ohshima Y, Okada M. Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans. FEBS Lett. 2003;534:133-8 pubmed
    ..RNA interference of src-1, but not that of kin-22, caused a developmental arrest in early development. These results suggest that SRC-1 and KIN-22 play distinct roles under the control of CSK-1. ..
  6. Lee J, Li W, Guan K. SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans. Mol Cell Biol. 2005;25:6485-95 pubmed
  7. Takata N, Itoh B, Misaki K, Hirose T, Yonemura S, Okada M. Non-receptor tyrosine kinase CSK-1 controls pharyngeal muscle organization in Caenorhabditis elegans. Genes Cells. 2009;14:381-93 pubmed publisher
    ..These results suggest that CSK-1 has an essential function in organization of pharyngeal muscle filaments that does not require C. elegans SFKs. ..
  8. Masuda H, Nakamura K, Takata N, Itoh B, Hirose T, Moribe H, et al. MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans. FEBS Lett. 2012;586:740-6 pubmed publisher
    ..The unc-71 mutation also rescued the anterior migration defect of AVM neuron in src-1 mutants. These findings suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans. ..
  9. Kim S, Ishidate T, Sharma R, Soto M, Conte D, Mello C, et al. Wnt and CDK-1 regulate cortical release of WRM-1/?-catenin to control cell division orientation in early Caenorhabditis elegans embryos. Proc Natl Acad Sci U S A. 2013;110:E918-27 pubmed publisher
    ..Our findings are consistent with a model in which Wnt signaling and CDK-1 modify WRM-1 in a temporal and spatial manner to unmask an intrinsic polarity cue required for proper orientation of the EMS cell division axis. ..

More Information


  1. Hsu T, Wu Y. Engulfment of apoptotic cells in C. elegans is mediated by integrin alpha/SRC signaling. Curr Biol. 2010;20:477-86 pubmed publisher
  2. Tsou M, Hayashi A, Rose L. LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling. Development. 2003;130:5717-30 pubmed
    ..These results provide insight into how polarity cues are transmitted into specific spindle positions in both extrinsic and intrinsic pathways of asymmetric cell division. ..
  3. Walston T, Tuskey C, Edgar L, Hawkins N, Ellis G, Bowerman B, et al. Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev Cell. 2004;7:831-41 pubmed
  4. Zhang H, Skop A, White J. Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos. J Cell Sci. 2008;121:155-61 pubmed publisher
    ..By RNAi of a weak dnc-1(ts) allele, we showed that dynactin activity was required at least for EMS spindle rotational alignment. ..