Gene Symbol: spd-1
Description: hypothetical protein
Species: Caenorhabditis elegans
Baruni J, Munro E, Von Dassow G. Cytokinetic furrowing in toroidal, binucleate and anucleate cells in C. elegans embryos. J Cell Sci. 2008;121:306-16 pubmed publisher
..However, furrows that cross a central spindle are more likely to complete than those that do not. ..
Smith K, Kieserman E, Wang P, Basten S, Giles R, Marcotte E, et al
. A role for central spindle proteins in cilia structure and function. Cytoskeleton (Hoboken). 2011;68:112-24 pubmed publisher
..These mutants displayed defects in both cilia function and cilia morphology. Together, these data suggest the conserved reuse of a surprisingly large number of proteins in the cytokinetic apparatus and in cilia. ..
O Connell K, Leys C, White J. A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans. Genetics. 1998;149:1303-21 pubmed
..We conclude that this approach can be used to identify mutations that affect various aspects of the cell-division cycle. ..
Nahaboo W, Zouak M, Askjaer P, Delattre M. Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner. Mol Biol Cell. 2015;26:2020-9 pubmed publisher
..Their involvement raises the interesting possibility that microtubule polymerization of midzone microtubules is continuously required to sustain chromosome segregation during mitosis. ..
Verbrugghe K, White J. SPD-1 is required for the formation of the spindle midzone but is not essential for the completion of cytokinesis in C. elegans embryos. Curr Biol. 2004;14:1755-60 pubmed
..Also, it can localize to the midzone when other midzone components are depleted, suggesting that SPD-1 may play an early role in the pathway of midzone assembly. ..
Lee K, Esmaeili B, Zealley B, Mishima M. Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle. Nat Commun. 2015;6:7290 pubmed publisher
..This mechanism involves the direct interaction of two different types of conserved microtubule bundlers that are crucial for central spindle formation, PRC1 and centralspindlin. ..
Mullen T, Wignall S. Interplay between microtubule bundling and sorting factors ensures acentriolar spindle stability during C. elegans oocyte meiosis. PLoS Genet. 2017;13:e1006986 pubmed publisher
..Therefore, our studies have revealed an interplay between distinct mechanisms that together promote spindle formation and chromosome segregation in the absence of structural cues such as centrioles. ..