Gene Symbol: soc-2
Description: Leucine-rich repeat protein soc-2;Suppressor Of Clr
Alias: Leucine-rich repeat protein soc-2;Suppressor Of Clr
Species: Caenorhabditis elegans

Top Publications

  1. Selfors L, Schutzman J, Borland C, Stern M. soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling. Proc Natl Acad Sci U S A. 1998;95:6903-8 pubmed
    ..We conclude that this genetic system has allowed for the identification of a conserved gene implicated in mediating FGF receptor signaling in C. elegans. ..
  2. Sieburth D, Sun Q, Han M. SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. Cell. 1998;94:119-30 pubmed
    ..A structural and functional SUR-8 homolog in humans specifically binds K-Ras and N-Ras but not H-Ras in vitro...
  3. Howard R, Sundaram M. C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component. Genes Dev. 2002;16:1815-27 pubmed
    ..Further studies of eor-1 and eor-2 may provide insight into the roles of PLZF in normal development and leukemogenesis. ..
  4. Dixon S, Alexander M, Fernandes R, Ricker N, Roy P. FGF negatively regulates muscle membrane extension in Caenorhabditis elegans. Development. 2006;133:1263-75 pubmed
    ..Our data are consistent with a model in which integrins and laminins are needed for directed muscle arm extension to the nerve cords, while FGF signaling provides a general mechanism to regulate muscle membrane extension. ..