Gene Symbol: smg-2
Description: Regulator of nonsense transcripts 1
Alias: Regulator of nonsense transcripts 1
Species: Caenorhabditis elegans
Products:     smg-2

Top Publications

  1. Hodgkin J, Papp A, Pulak R, Ambros V, Anderson P. A new kind of informational suppression in the nematode Caenorhabditis elegans. Genetics. 1989;123:301-13 pubmed
    ..This suggests that the smg suppressors affect a process other than translation, for example mRNA processing, transport, or stability. ..
  2. Anders K, Grimson A, Anderson P. SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. EMBO J. 2003;22:641-50 pubmed
    ..Our results suggest that PP2A is the SMG-2 phosphatase, and the role of SMG-5 is to direct PP2A to its SMG-2 substrate. We discuss cycles of SMG-2 phosphorylation and their roles in NMD. ..
  3. Page M, Carr B, Anders K, Grimson A, Anderson P. SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol Cell Biol. 1999;19:5943-51 pubmed
    ..We discuss these results with regard to the in vivo functions of SMG-2 and NMD...
  4. Hodgkin J. Sex determination in the nematode C. elegans: analysis of tra-3 suppressors and characterization of fem genes. Genetics. 1986;114:15-52 pubmed
    ..Maternal contributions of wild-type fem-3 product are necessary for normal XO male development and XX hermaphrodite (as opposed to female) development. ..
  5. Mitrovich Q, Anderson P. Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans. Genes Dev. 2000;14:2173-84 pubmed
    ..We demonstrate further that alternative splicing of rpl introns is conserved among widely diverged nematodes. Our results suggest that one important role of mRNA surveillance is to eliminate unproductive by-products of gene regulation. ..
  6. Domeier M, Morse D, Knight S, Portereiko M, Bass B, Mango S. A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans. Science. 2000;289:1928-31 pubmed
    ..The levels of target messenger RNAs were restored during recovery, and RNA editing and degradation of the dsRNA were identical to those of the wild type. We suggest that persistence of RNA interference relies on a subset of smg genes. ..
  7. Kim J, Gabel H, Kamath R, Tewari M, Pasquinelli A, Rual J, et al. Functional genomic analysis of RNA interference in C. elegans. Science. 2005;308:1164-7 pubmed
    ..Moreover, the physical interactions among these potential RNAi factors suggest links to other RNA-dependent gene regulatory pathways. ..
  8. Blanchard D, Hutter H, Fleenor J, Fire A. A differential cytolocalization assay for analysis of macromolecular assemblies in the eukaryotic cytoplasm. Mol Cell Proteomics. 2006;5:2175-84 pubmed
  9. Johns L, Grimson A, Kuchma S, Newman C, Anderson P. Caenorhabditis elegans SMG-2 selectively marks mRNAs containing premature translation termination codons. Mol Cell Biol. 2007;27:5630-8 pubmed
    ..We discuss these observations with regard to the functions of SMG-2 and its phosphorylation during NMD. ..

More Information


  1. Longman D, Hug N, Keith M, Anastasaki C, Patton E, Grimes G, et al. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Nucleic Acids Res. 2013;41:8319-31 pubmed publisher
    ..Furthermore, the conservation of a mechanism to tightly control NMD homeostasis across different species highlights the importance of the NMD response in the control of gene expression. ..
  2. Mango S. Stop making nonSense: the C. elegans smg genes. Trends Genet. 2001;17:646-53 pubmed
    ..Here I describe what is known about the smg genes and their potential functions in these two mRNA degradation pathways. ..
  3. Gu W, Shirayama M, Conte D, Vasale J, Batista P, Claycomb J, et al. Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell. 2009;36:231-44 pubmed publisher
    ..These findings broaden our understanding of the biogenesis and diversity of 22G-RNAs and suggest additional regulatory functions for small RNAs. ..