Gene Symbol: sma-4
Description: Dwarfin sma-4;SMAll
Alias: Dwarfin sma-4;SMAll
Species: Caenorhabditis elegans
Maduzia L, Gumienny T, Zimmerman C, Wang H, Shetgiri P, Krishna S, et al
. lon-1 regulates Caenorhabditis elegans body size downstream of the dbl-1 TGF beta signaling pathway. Dev Biol. 2002;246:418-28 pubmed
..This provides evidence that lon-1 is negatively regulated by Sma/Mab pathway signaling. Taken together, these data identify lon-1 as a novel downstream target gene of the dbl-1 TGF beta-like signaling pathway. ..
Liu Z, Shi H, Szymczak L, Aydin T, Yun S, Constas K, et al
. Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids. PLoS Genet. 2015;11:e1005221 pubmed publisher
Krishna S, Maduzia L, Padgett R. Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans. Development. 1999;126:251-60 pubmed
..These findings distinguish between the manner in which signaling specificity is achieved in TGFbeta-like pathways and receptor tyrosine-kinase (RTK) pathways. ..
Wang J, Tokarz R, Savage Dunn C. The expression of TGFbeta signal transducers in the hypodermis regulates body size in C. elegans. Development. 2002;129:4989-98 pubmed
..As dbl-1 is expressed primarily in the nervous system, these results suggest a model in which postembryonic growth of hypodermal cells is regulated by TGFbeta-related signaling from the nervous system to the hypodermis. ..
Wang J, Mohler W, Savage Dunn C. C-terminal mutants of C. elegans Smads reveal tissue-specific requirements for protein activation by TGF-beta signaling. Development. 2005;132:3505-13 pubmed
Tischler J, Lehner B, Chen N, Fraser A. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Genome Biol. 2006;7:R69 pubmed
Savage Dunn C, Maduzia L, Zimmerman C, Roberts A, Cohen S, Tokarz R, et al
. Genetic screen for small body size mutants in C. elegans reveals many TGFbeta pathway components. Genesis. 2003;35:239-47 pubmed
..Because of the conservation of TGFbeta signaling pathways, homologs of these genes may be involved in tissue specificity and/or crosstalk of TGFbeta pathways in other animals. ..
Watanabe N, Ishihara T, Ohshima Y. Mutants carrying two sma mutations are super small in the nematode C. elegans. Genes Cells. 2007;12:603-9 pubmed
..These results highlight surprising flexibility of body size and cell size in a multicellular organism, which will give a novel insight into the mechanisms of body size control. ..