Gene Symbol: skr-2
Description: SKp1 Related (ubiquitin ligase complex component)
Alias: SKp1 Related (ubiquitin ligase complex component)
Species: Caenorhabditis elegans
Yamanaka A, Yada M, Imaki H, Koga M, Ohshima Y, Nakayama K. Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins. Curr Biol. 2002;12:267-75 pubmed
..At least eight of the SKR proteins may, like F-box proteins, act as variable components of the SCF complex in C. elegans. ..
Nayak S, Santiago F, Jin H, Lin D, Schedl T, Kipreos E. The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis. Curr Biol. 2002;12:277-87 pubmed
..elegans perform critical functions in regulating cell proliferation, meiosis, and morphogenesis. The finding that multiple SKRs are able to bind cullins suggests an extensive set of combinatorial SCF complexes. ..
Peel N, Dougherty M, Goeres J, Liu Y, O Connell K. The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels. J Cell Sci. 2012;125:3535-44 pubmed
..Co-depletion of LIN-23 and SEL-10 suggests these proteins function cooperatively. Because SEL-10 is the homolog of human FBW7, which is frequently mutated in cancer, our findings have implications for understanding tumorigenesis...
Wu C, Deonarine A, Przybysz A, Strange K, Choe K. The Skp1 Homologs SKR-1/2 Are Required for the Caenorhabditis elegans SKN-1 Antioxidant/Detoxification Response Independently of p38 MAPK. PLoS Genet. 2016;12:e1006361 pubmed publisher
..Together, these results identify a novel p38 MAPK independent signaling mechanism that activates SKN-1 via SKR-1/2 and involves WDR-23. ..
Popovici C, Berda Y, Conchonaud F, Harbis A, Birnbaum D, Roubin R. Direct and heterologous approaches to identify the LET-756/FGF interactome. BMC Genomics. 2006;7:105 pubmed
..The interactors identified play various roles in developmental process or basic biochemical events such as ribosome biogenesis. ..
Gao M, Liao E, Yu B, Wang Y, Zhen M, Derry W. The SCF FSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans. Cell Death Differ. 2008;15:1054-62 pubmed publisher
..Our results uncover a novel role for the SCF(FSN-1) E3 ubiquitin ligase in the regulation of cep-1-dependent germ cell apoptosis. ..
Labocha M, Jung S, Aleman Meza B, Liu Z, Zhong W. WormGender - Open-Source Software for Automatic Caenorhabditis elegans Sex Ratio Measurement. PLoS ONE. 2015;10:e0139724 pubmed publisher
..The source code is freely available together with a user manual and sample data at http://www.QuantWorm.org/. The source code and sample data are also available at http://dx.doi.org/10.6084/m9.figshare.1541248. ..