Genomes and Genes
Gene Symbol: sir-2.1
Description: NAD-dependent protein deacetylase sir-2.1;yeast SIR related
Alias: NAD-dependent protein deacetylase sir-2.1;yeast SIR related
Species: Caenorhabditis elegans
- Wang Y, Oh S, Deplancke B, Luo J, Walhout A, Tissenbaum H. C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev. 2006;127:741-7 pubmed..Finally, we show that DAF-16/FOXO also physically interacts with the 14-3-3 proteins. These results suggest that C. elegans 14-3-3 proteins can regulate longevity by cooperating with both SIR-2.1 and DAF-16/FOXO. ..
- Guo X, Garcia L. SIR-2.1 integrates metabolic homeostasis with the reproductive neuromuscular excitability in early aging male Caenorhabditis elegans. elife. 2014;3:e01730 pubmed publisher..DOI: http://dx.doi.org/10.7554/eLife.01730.001. ..
- Kashyap S, Johnson J, McCue H, Chen X, Edmonds M, Ayala M, et al. Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol. Hum Mol Genet. 2014;23:5916-27 pubmed publisher..The Sirtuin-independent neuroprotective action of resveratrol revealed here suggests potential therapeutic applications for ANCL and possibly other human neurodegenerative diseases. ..
- Mouchiroud L, Houtkooper R, Moullan N, Katsyuba E, Ryu D, Canto C, et al. The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell. 2013;154:430-41 pubmed publisher..Our data suggest that augmenting mitochondrial stress signaling through the modulation of NAD(+) levels may be a target to improve mitochondrial function and prevent or treat age-associated decline. ..
- Wang X, Wang X, Li L, Wang D. Lifespan extension in Caenorhabditis elegans by DMSO is dependent on sir-2.1 and daf-16. Biochem Biophys Res Commun. 2010;400:613-8 pubmed publisher..1 and daf-16 but not eat-2 or hsf-1. In summary, we report the function and the putative mechanism of DMSO in lifespan extension of C. elegans. This study draws attention to using DMSO as a solvent when conducting aging studies. ..
- Jadiya P, Chatterjee M, Sammi S, Kaur S, Palit G, Nazir A. Sir-2.1 modulates 'calorie-restriction-mediated' prevention of neurodegeneration in Caenorhabditis elegans: implications for Parkinson's disease. Biochem Biophys Res Commun. 2011;413:306-10 pubmed publisher..Our studies provide evidence that calorie restriction affords, an sir-2.1 mediated, protection against the dopaminergic neurodegeneration, that might have implications for neurodegenerative Parkinson's disease. ..
- Raynes R, Leckey B, Nguyen K, Westerheide S. Heat shock and caloric restriction have a synergistic effect on the heat shock response in a sir2.1-dependent manner in Caenorhabditis elegans. J Biol Chem. 2012;287:29045-53 pubmed publisher..1-dependent manner. Finally, we show that caloric restriction increases the ability of heat shock to preserve movement in a polyglutamine toxicity neurodegenerative disease model and that this effect is dependent on sir2.1. ..
- Ludewig A, Izrayelit Y, Park D, Malik R, Zimmermann A, Mahanti P, et al. Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1. Proc Natl Acad Sci U S A. 2013;110:5522-7 pubmed publisher..These findings strengthen the link between chemosensory inputs and conserved mechanisms of lifespan regulation in metazoans and suggest a model for communal lifespan regulation in C. elegans...
- Heidler T, Hartwig K, Daniel H, Wenzel U. Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1. Biogerontology. 2010;11:183-95 pubmed publisher..1-dependent alterations in gene expression after a ROS challenge lead to a lifespan extension in C. elegans as long as the stressor concentration does not exceed the saturable protective capacity. ..
- Pan K, Palter J, Rogers A, Olsen A, Chen D, Lithgow G, et al. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell. 2007;6:111-9 pubmed..Thus, mRNA translation exerts pleiotropic effects on growth, reproduction, stress resistance and lifespan in C. elegans. ..
- Mair W, Panowski S, Shaw R, Dillin A. Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans. PLoS ONE. 2009;4:e4535 pubmed publisher..1, highlighting the importance of first optimizing DR to identify universal regulators of DR mediated longevity. ..
- Parker J, Vázquez Manrique R, Tourette C, Farina F, Offner N, Mukhopadhyay A, et al. Integration of ?-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity. J Neurosci. 2012;32:12630-40 pubmed publisher..Taken together, these results suggest that integration of ?-catenin, sirtuin and FOXO signaling protects from the early phases of mutant huntingtin toxicity. ..
- Fitzenberger E, Deusing D, Marx C, Boll M, Lüersen K, Wenzel U. The polyphenol quercetin protects the mev-1 mutant of Caenorhabditis elegans from glucose-induced reduction of survival under heat-stress depending on SIR-2.1, DAF-12, and proteasomal activity. Mol Nutr Food Res. 2014;58:984-94 pubmed publisher..SIR-2.1, DAF-12, and MDT-15 were identified as targets that activate unfolded protein response and proteasomal degradation to limit the accumulation of functionally restricted proteins. ..
- Morselli E, Maiuri M, Markaki M, Megalou E, Pasparaki A, Palikaras K, et al. The life span-prolonging effect of sirtuin-1 is mediated by autophagy. Autophagy. 2010;6:186-8 pubmed..elegans, our results suggest that caloric restriction and resveratrol extend longevity, at least in experimental settings, by activating autophagy. ..
- Berdichevsky A, Nedelcu S, Boulias K, Bishop N, Guarente L, Horvitz H. 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1. Proc Natl Acad Sci U S A. 2010;107:18927-32 pubmed publisher..Our findings suggest that defects in fatty acid oxidation can limit lifespan and accelerate aging in C. elegans and that kat-1-mediated fatty acid oxidation is crucial for overexpressed sir-2.1 to delay aging. ..
- Hashimoto T, Horikawa M, Nomura T, Sakamoto K. Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16. Biogerontology. 2010;11:31-43 pubmed publisher..1 and DAF-16 along a signaling pathway, namely insulin-like signalling pathway (at least parts of it), different from that associated with caloric restriction. ..
- Wirth M, Paap F, Fischle W, Wenzel D, Agafonov D, Samatov T, et al. HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in the Caenorhabditis elegans germ line. Mol Cell Biol. 2009;29:3700-9 pubmed publisher..Overall, our data indicate that SIR-2.1 and HIS-24 contribute to the propagation of a specialized chromatin state at the subtelomeric regions and elsewhere in the genome. ..