Gene Symbol: shn-1
Description: Protein shank
Alias: Protein shank
Species: Caenorhabditis elegans

Top Publications

  1. Jee C, Lee J, Lee J, Lee W, Park B, Yu J, et al. SHN-1, a Shank homologue in C. elegans, affects defecation rhythm via the inositol-1,4,5-trisphosphate receptor. FEBS Lett. 2004;561:29-36 pubmed
    ..Our data suggest a possible role of SHN-1 in affecting function of IP(3) receptors in C. elegans. ..
  2. Lenfant N, Polanowska J, Bamps S, Omi S, Borg J, Reboul J. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. BMC Genomics. 2010;11:671 pubmed publisher
    ..The protein interactions from this publication have been submitted to the IMEx ( consortium through IntAct (PMID: 19850723) and assigned the identifier IM-14654]. ..
  3. Oh W, Song H, Cho J, Park B. ANK repeat-domain of SHN-1 Is indispensable for in vivo SHN-1 function in C. elegans. Mol Cells. 2011;31:79-84 pubmed publisher
    ..Thus, we suggest that Shank ANK repeat-domain along with PDZ may play a crucial role in regulating Ca²+-signaling with IP? receptor. ..
  4. Pym E, Sasidharan N, Thompson Peer K, Simon D, Anselmo A, Sadreyev R, et al. Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression. elife. 2017;6: pubmed publisher
    ..These results suggest that an important function of Shank proteins is to regulate L-channel current and activity induced gene expression. ..