Gene Symbol: sgk-1
Description: Serine/threonine-protein kinase sgk-1
Alias: Serine/threonine-protein kinase sgk-1
Species: Caenorhabditis elegans
Hertweck M, Göbel C, Baumeister R. C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell. 2004;6:577-88 pubmed
..Our data also suggest the existence of a second pathway from DAF-2 to DAF-16 that does not depend on AKT-1, AKT-2, and SGK-1. ..
Jones K, Greer E, Pearce D, Ashrafi K. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol. 2009;7:e60 pubmed publisher
..These findings identify new physiological roles for TORC2, mediated by SGK, in regulation of C. elegans lipid accumulation and growth, and they challenge the notion that AKT is the primary effector of TORC2 function. ..
Tullet J, Hertweck M, An J, Baker J, Hwang J, Liu S, et al
. Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell. 2008;132:1025-38 pubmed publisher
..Furthermore, SKN-1 that is constitutively active increases life span independently of DAF-16. Our findings indicate that the transcription network regulated by SKN-1 promotes longevity and is an important direct target of IIS. ..
Soukas A, Kane E, Carr C, Melo J, Ruvkun G. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev. 2009;23:496-511 pubmed publisher
..These data indicate that Rictor/TORC2 is a nutrient-sensitive complex with outputs to AKT and SGK to modulate the assessment of food quality and signal to fat metabolism, growth, feeding behavior, reproduction, and life span. ..
Ruf V, Holzem C, Peyman T, Walz G, Blackwell T, Neumann Haefelin E. TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development. Dev Biol. 2013;384:214-27 pubmed publisher
..The SGK-1 kinase mediated these functions downstream of rict-1/TORC2, as a sgk-1 gain-of-function mutant suppressed the rict-1 mutant phenotype. These data indicate that TORC2 and SGK-1 antagonize SKN-1 during embryonic development...
Nakagawa A, Sullivan K, Xue D. Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway. Nat Struct Mol Biol. 2014;21:1082-90 pubmed publisher
..Our findings reveal a new mechanism that negatively regulates AKT cell signaling to promote apoptosis and that may restrict cell growth and proliferation in normal cells. ..
Zhu M, Wu G, Li Y, Stevens J, Fan C, Spang A, et al
. Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans. PLoS ONE. 2015;10:e0130778 pubmed publisher
..We propose that SGK-1 function is required for lipid homeostasis and that it acts at different intracellular trafficking steps. ..