Gene Symbol: sem-5
Description: Sex muscle abnormal protein 5
Alias: Sex muscle abnormal protein 5
Species: Caenorhabditis elegans
Chamberlin H, Sternberg P. The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans. Development. 1994;120:2713-21 pubmed
..We have also investigated the role of lin-12 in forming the anterior/posterior pattern of fates. A lin-12 gain-of-function defect is masked by redundant positional information from F and U. ..
Katz W, Lesa G, Yannoukakos D, Clandinin T, Schlessinger J, Sternberg P. A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog. Mol Cell Biol. 1996;16:529-37 pubmed
..The fates produced depended on the copy number of the mutation, suggesting that quantitative differences in receptor activity influence the decision between these two fates. ..
Ferreon J, Volk D, Luxon B, Gorenstein D, Hilser V. Solution structure, dynamics, and thermodynamics of the native state ensemble of the Sem-5 C-terminal SH3 domain. Biochemistry. 2003;42:5582-91 pubmed
..The implications of this agreement and the potential role of conformational heterogeneity of the observed biophysical properties are discussed. ..
Dixon S, Alexander M, Fernandes R, Ricker N, Roy P. FGF negatively regulates muscle membrane extension in Caenorhabditis elegans. Development. 2006;133:1263-75 pubmed
..Our data are consistent with a model in which integrins and laminins are needed for directed muscle arm extension to the nerve cords, while FGF signaling provides a general mechanism to regulate muscle membrane extension. ..
Zhu Z, Chai Y, Jiang Y, Li W, Hu H, Li W, et al
. Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration. Dev Cell. 2016;39:224-238 pubmed publisher
Clark S, Stern M, Horvitz H. C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature. 1992;356:340-4 pubmed
..Our results indicate that the sem-5 gene encodes a novel protein that functions in at least two distinct cell-signalling processes. ..
Stern M, Marengere L, Daly R, Lowenstein E, Kokel M, Batzer A, et al
. The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5. Mol Biol Cell. 1993;4:1175-88 pubmed
..These data indicate that GRB2 and Drk are functional homologues of Sem-5 and demonstrate the high degree of conservation of both structure and function between signaling systems throughout evolution. ..
Ferguson M, Fan X, Mukherjee M, Luo J, Khan R, Ferreon J, et al
. Directed discovery of bivalent peptide ligands to an SH3 domain. Protein Sci. 2004;13:626-32 pubmed
..PP-G(4)-L may aid in the discovery of additional binding partners of Grb2 family SH3 domains. ..