sdc-2

Summary

Gene Symbol: sdc-2
Description: Sex determination and dosage compensation protein sdc-2
Alias: Sex determination and dosage compensation protein sdc-2
Species: Caenorhabditis elegans

Top Publications

  1. Trent C, Purnell B, Gavinski S, Hageman J, Chamblin C, Wood W. Sex-specific transcriptional regulation of the C. elegans sex-determining gene her-1. Mech Dev. 1991;34:43-55 pubmed
    ..This mode of regulation contrasts with that found for the Drosophila sex-determining genes, whose sex-specific expression is controlled by differential splicing in males and females. ..
  2. Nusbaum C, Meyer B. The Caenorhabditis elegans gene sdc-2 controls sex determination and dosage compensation in XX animals. Genetics. 1989;122:579-93 pubmed
    ..We propose a model in which sdc-2 is involved in the coordinate control of both sex determination and dosage compensation in XX animals and acts in the regulatory hierarchy at a step prior to the divergence of the two pathways. ..
  3. Chu D, Dawes H, Lieb J, Chan R, Kuo A, Meyer B. A molecular link between gene-specific and chromosome-wide transcriptional repression. Genes Dev. 2002;16:796-805 pubmed
  4. Sharma R, Jost D, Kind J, Gómez Saldivar G, van Steensel B, Askjaer P, et al. Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans. Genes Dev. 2014;28:2591-6 pubmed publisher
    ..Our results put forward a structural model of DC in which X-specific sequences locate the X chromosome in transcriptionally active domains in males, while the DCC prevents this in hermaphrodites. ..