Gene Symbol: sax-7
Description: Sensory AXon guidance
Alias: Sensory AXon guidance
Species: Caenorhabditis elegans
Products:     sax-7

Top Publications

  1. Sasakura H, Inada H, Kuhara A, Fusaoka E, Takemoto D, Takeuchi K, et al. Maintenance of neuronal positions in organized ganglia by SAX-7, a Caenorhabditis elegans homologue of L1. EMBO J. 2005;24:1477-88 pubmed
    ..We propose that both homophilic and heterophilic interactions of SAX-7 are essential for maintenance of neuronal positions in organized ganglia. ..
  2. Pocock R, Benard C, Shapiro L, Hobert O. Functional dissection of the C. elegans cell adhesion molecule SAX-7, a homologue of human L1. Mol Cell Neurosci. 2008;37:56-68 pubmed
    ..Lastly, we show that of the several protein binding motifs present in the intracellular region of SAX-7, only its ankyrin binding motif is required and also solely sufficient to confer the adhesive functions of SAX-7. ..
  3. Zhou S, Opperman K, Wang X, Chen L. unc-44 Ankyrin and stn-2 gamma-syntrophin regulate sax-7 L1CAM function in maintaining neuronal positioning in Caenorhabditis elegans. Genetics. 2008;180:1429-43 pubmed publisher
    ..Furthermore, we provide molecular and genetic evidence that UNC-44 ankyrin and STN-2 gamma-syntrophin bind SAX-7 via the respective ankyrin-binding and PDZ-binding motifs to regulate SAX-7 function in maintaining neuronal positioning. ..
  4. Salzberg Y, Díaz Balzac C, Ramirez Suarez N, Attreed M, Tecle E, Desbois M, et al. Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans. Cell. 2013;155:308-20 pubmed publisher
    ..Our data describe an unknown pathway that provides spatial information from the skin substrate to pattern sensory dendrite development nonautonomously. ..
  5. Moorthy S, Chen L, Bennett V. Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function. J Cell Biol. 2000;149:915-30 pubmed
    ..We hypothesize that heteromeric spectrin evolved in metazoans in response to the needs of cells in the context of mechanically integrated tissues that can withstand the rigors imposed by an active organism. ..
  6. Chen L, Ong B, Bennett V. LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling. J Cell Biol. 2001;154:841-55 pubmed
    ..Taken together, these results indicate that L1CAMs constitute a family of ubiquitous adhesion molecules, which participate in tissue morphogenesis and maintaining tissue integrity in metazoans. ..
  7. Dong X, Liu O, Howell A, Shen K. An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis. Cell. 2013;155:296-307 pubmed publisher
    ..Ectopic expression of SAX-7 and MNR-1 generates a predictable, unnaturally patterned dendritic tree in a DMA-1-dependent manner. Both in vivo and in vitro experiments indicate that all three molecules are needed for interaction. ..
  8. Grana T, Cox E, Lynch A, Hardin J. SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation. Dev Biol. 2010;344:731-44 pubmed publisher
  9. Benard C, Blanchette C, Recio J, Hobert O. The secreted immunoglobulin domain proteins ZIG-5 and ZIG-8 cooperate with L1CAM/SAX-7 to maintain nervous system integrity. PLoS Genet. 2012;8:e1002819 pubmed publisher
    ..Apart from extending our understanding of dedicated neuronal maintenance mechanisms, these findings provide novel insights into adhesive and anti-adhesive functions of IgCAM proteins. ..

More Information


  1. Zhou S, Chen L. Neural integrity is maintained by dystrophin in C. elegans. J Cell Biol. 2011;192:349-63 pubmed publisher
    ..elegans. This study provides biochemical data that show that SAX-7 associates with DYS-1 in an STN-2/?-syntrophin-dependent manner. These results reveal a recruitment of L1CAMs to the DPC to ensure neural integrity is maintained. ..
  2. Salzberg Y, Ramirez Suarez N, Bülow H. The proprotein convertase KPC-1/furin controls branching and self-avoidance of sensory dendrites in Caenorhabditis elegans. PLoS Genet. 2014;10:e1004657 pubmed publisher
    ..We propose that KPC-1/furin acts in concert with the 'menorin' pathway to control branching and growth of somatosensory dendrites in PVD. ..
  3. Dong X, Chiu H, Park Y, Zou W, Zou Y, Özkan E, et al. Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions. elife. 2016;5: pubmed publisher
    ..The misregulation of DMA-1 also causes dendritic self-avoidance defects. Thus, precise regulation of guidance receptors creates flexibility of responses to guidance signals and is critical for neuronal morphogenesis. ..