Gene Symbol: sas-6
Description: Spindle assembly abnormal protein 6
Alias: Spindle assembly abnormal protein 6
Species: Caenorhabditis elegans
Leidel S, Delattre M, Cerutti L, Baumer K, GONCZY P. SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Nat Cell Biol. 2005;7:115-25 pubmed
..Therefore, HsSAS-6 is also required for centrosome duplication, indicating that the function of SAS-6-related proteins has been widely conserved during evolution. ..
Kitagawa D, Busso C, Flückiger I, GONCZY P. Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos. Dev Cell. 2009;17:900-7 pubmed publisher
..Overall, our findings establish that phosphorylation of the evolutionarily conserved protein SAS-6 is critical for centriole formation and thus for faithful cell division...
Essex A, Dammermann A, Lewellyn L, Oegema K, Desai A. Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches. Mol Biol Cell. 2009;20:1252-67 pubmed publisher
..We discuss the rationale for a bipartite checkpoint mechanism in which a core Mad1(MDF-1)/Mad2(MDF-2) signal generated at kinetochores is integrated with a separate cytoplasmic Mad3(SAN-1)/BUB-3-based pathway. ..
Kitagawa D, Vakonakis I, Olieric N, Hilbert M, Keller D, Olieric V, et al
. Structural basis of the 9-fold symmetry of centrioles. Cell. 2011;144:364-75 pubmed publisher
..Overall, our findings establish a structural basis for the universal 9-fold symmetry of centrioles. ..
Song M, Liu Y, Anderson D, Jahng W, O Connell K. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011;20:563-71 pubmed publisher
..Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation. ..
O Rourke S, Yochem J, Connolly A, Price M, Carter L, Lowry J, et al
. Rapid mapping and identification of mutations in Caenorhabditis elegans by restriction site-associated DNA mapping and genomic interval pull-down sequencing. Genetics. 2011;189:767-78 pubmed publisher
..Together, these two methods provide a rapid and cost-effective approach for positional cloning of C. elegans mutant loci, and are also applicable to other genetic model systems. ..
Qiao R, Cabral G, Lettman M, Dammermann A, Dong G. SAS-6 coiled-coil structure and interaction with SAS-5 suggest a regulatory mechanism in C. elegans centriole assembly. EMBO J. 2012;31:4334-47 pubmed publisher
Lettman M, Wong Y, Viscardi V, Niessen S, Chen S, Shiau A, et al
. Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly. Dev Cell. 2013;25:284-98 pubmed publisher
..We propose that ZYG-1 binding to the SAS-6 coiled coil recruits the SAS-6-SAS-5 complex to the mother centriole, where a ZYG-1 kinase activity-dependent step, whose target is unlikely to be SAS-6, triggers cartwheel assembly. ..