Gene Symbol: sas-5
Description: Spindle assembly abnormal protein 5
Alias: Spindle assembly abnormal protein 5
Species: Caenorhabditis elegans
Schmutz C, Spang A. Knockdown of the centrosomal component SAS-5 results in defects in nuclear morphology in Caenorhabditis elegans. Eur J Cell Biol. 2005;84:75-82 pubmed
..Yet, this dispersion did neither trigger apoptosis nor affect nuclear envelope assembly. No intrinsic size control for the nucleus seems to exist in the early embryo. ..
Song M, Liu Y, Anderson D, Jahng W, O Connell K. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011;20:563-71 pubmed publisher
..Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation. ..
Delattre M, Leidel S, Wani K, Baumer K, Bamat J, Schnabel H, et al
. Centriolar SAS-5 is required for centrosome duplication in C. elegans. Nat Cell Biol. 2004;6:656-64 pubmed
..Furthermore, partial RNA-interference (RNAi)-mediated inactivation experiments suggest that both sas-5 and zyg-1 are dose-dependent regulators of centrosome duplication. ..
Leidel S, Delattre M, Cerutti L, Baumer K, GONCZY P. SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Nat Cell Biol. 2005;7:115-25 pubmed
..Therefore, HsSAS-6 is also required for centrosome duplication, indicating that the function of SAS-6-related proteins has been widely conserved during evolution. ..
Qiao R, Cabral G, Lettman M, Dammermann A, Dong G. SAS-6 coiled-coil structure and interaction with SAS-5 suggest a regulatory mechanism in C. elegans centriole assembly. EMBO J. 2012;31:4334-47 pubmed publisher
Rogala K, Dynes N, Hatzopoulos G, Yan J, Pong S, Robinson C, et al
. The Caenorhabditis elegans protein SAS-5 forms large oligomeric assemblies critical for centriole formation. elife. 2015;4:e07410 pubmed publisher
..Disruption of either domain leads to centriole duplication failure in worm embryos, indicating that large SAS-5 assemblies are necessary for function in vivo. ..
Dammermann A, MULLER REICHERT T, Pelletier L, Habermann B, Desai A, Oegema K. Centriole assembly requires both centriolar and pericentriolar material proteins. Dev Cell. 2004;7:815-29 pubmed
..Thus, both centriolar and pericentriolar material proteins contribute to centriole assembly. ..