Gene Symbol: sas-4
Description: Spindle assembly abnormal protein 4
Alias: Spindle assembly abnormal protein 4
Species: Caenorhabditis elegans
Dammermann A, MULLER REICHERT T, Pelletier L, Habermann B, Desai A, Oegema K. Centriole assembly requires both centriolar and pericentriolar material proteins. Dev Cell. 2004;7:815-29 pubmed
..Thus, both centriolar and pericentriolar material proteins contribute to centriole assembly. ..
Kirkham M, MULLER REICHERT T, Oegema K, Grill S, Hyman A. SAS-4 is a C. elegans centriolar protein that controls centrosome size. Cell. 2003;112:575-87 pubmed
..Thus, SAS-4 is a centriole-associated component whose amount dictates centrosome size. These results provide novel insight into the poorly understood role of centrioles as centrosomal organizers. ..
Leidel S, GONCZY P. SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle. Dev Cell. 2003;4:431-9 pubmed
..Additional evidence indicates that SAS-4 is recruited to the daughter centriole or a closely associated structure. These findings identify SAS-4 recruitment as a key step in the centrosome duplication cycle. ..
Leidel S, Delattre M, Cerutti L, Baumer K, GONCZY P. SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Nat Cell Biol. 2005;7:115-25 pubmed
..Therefore, HsSAS-6 is also required for centrosome duplication, indicating that the function of SAS-6-related proteins has been widely conserved during evolution. ..
Robert V, Sijen T, van Wolfswinkel J, Plasterk R. Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes Dev. 2005;19:782-7 pubmed
..Together with molecular data also presented in this study, these results suggest that in C. elegans repetitive sequences trigger transcriptional gene silencing using RNAi and chromatin factors. ..
Dammermann A, Maddox P, Desai A, Oegema K. SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. J Cell Biol. 2008;180:771-85 pubmed publisher
..Such a mechanism may help restrict new centriole assembly to the vicinity of preexisting parent centrioles that recruit PCM...
Dammermann A, Pemble H, Mitchell B, McLeod I, Yates J, Kintner C, et al
. The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation. Genes Dev. 2009;23:2046-59 pubmed publisher
Song M, Liu Y, Anderson D, Jahng W, O Connell K. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011;20:563-71 pubmed publisher
..Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation. ..
Schvarzstein M, Pattabiraman D, BEMBENEK J, Villeneuve A. Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis. Proc Natl Acad Sci U S A. 2013;110:E898-907 pubmed publisher
..elegans also function to inhibit centriole separation at meiosis II, thereby ensuring that the zygote inherits the appropriate complement of chromosomes and centrioles...