Gene Symbol: sad-1
Description: Serine/threonine kinase SAD-1
Alias: Serine/threonine kinase SAD-1
Species: Caenorhabditis elegans

Top Publications

  1. Crump J, Zhen M, Jin Y, Bargmann C. The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination. Neuron. 2001;29:115-29 pubmed
    ..Overexpression of SAD-1 causes mislocalization of vesicle proteins to dendrites, suggesting that sad-1 affects axonal-dendritic polarity as well as synaptic development. ..
  2. Hung W, Hwang C, Po M, Zhen M. Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegans. Development. 2007;134:237-49 pubmed
    ..We propose that Neurabin functions as a scaffold to facilitate SAD-1-mediated phosphorylation for substrates specific for restricting axonal fate during neuronal polarization. ..
  3. Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, et al. Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 2013;48:191-201 pubmed publisher
  4. Edwards S, Morrison L, Yorks R, Hoover C, Boominathan S, Miller K. UNC-16 (JIP3) Acts Through Synapse-Assembly Proteins to Inhibit the Active Transport of Cell Soma Organelles to Caenorhabditis elegans Motor Neuron Axons. Genetics. 2015;201:117-41 pubmed publisher
    ..The data reveal a new and unprecedented role for synapse assembly proteins, acting as part of the newly defined CSS system, in mediating UNC-16's organelle transport regulatory function. ..
  5. Tanizawa Y, Kuhara A, Inada H, Kodama E, Mizuno T, Mori I. Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans. Genes Dev. 2006;20:3296-310 pubmed
    ..These results suggest that IMPase is required in central interneurons of the mature nervous system for correct localization of synaptic components and thus for normal behavior. ..
  6. Sakaguchi Nakashima A, Meir J, Jin Y, Matsumoto K, Hisamoto N. LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins. Curr Biol. 2007;17:592-8 pubmed
    ..These results suggest that the LRK-1 protein kinase determines polarized sorting of SV proteins to the axons by excluding SV proteins from the dendrite-specific transport machinery in the Golgi. ..
  7. Kim J, Lilley B, Zhang C, Shokat K, Sanes J, Zhen M. A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation. Neural Dev. 2008;3:23 pubmed publisher
    ..This study reports the first temporal analysis of a neural kinase activity using the chemical-genetic system. It reveals that neuronal polarity and synaptic organization have distinct temporal requirements for SAD-1. ..
  8. Kim J, Hung W, Narbonne P, Roy R, Zhen M. C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization. Development. 2010;137:93-102 pubmed publisher
    ..Our findings suggest that instead of a single, linear genetic pathway, STRADalpha and LKB1 regulate neuronal development through multiple effectors that are shared in some cellular contexts but distinct in others. ..
  9. Klassen M, Wu Y, Maeder C, Nakae I, Cueva J, Lehrman E, et al. An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation. Neuron. 2010;66:710-23 pubmed publisher
    ..Together, these results suggest that arl-8 promotes a trafficking identity for presynaptic cargoes, facilitating their efficient transport by repressing premature self-association. ..

More Information


  1. Yan X, Shen Y. Preliminary crystallographic analysis of the kinase domain of SAD-1, a protein essential for presynaptic differentiation in Caenorhabditis elegans. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013;69:449-52 pubmed publisher
    ..4, b = 57.1, c = 71.7 Å, ? = 106.1°. X-ray diffraction data were recorded to 3.0 Å resolution from a single crystal using synchrotron radiation. ..