Gene Symbol: rpt-2
Description: Probable 26S proteasome regulatory subunit 4
Alias: Probable 26S proteasome regulatory subunit 4
Species: Caenorhabditis elegans

Top Publications

  1. Lee S, Wong R, Chin C, Lim T, Eng S, Kong C, et al. Burkholderia pseudomallei suppresses Caenorhabditis elegans immunity by specific degradation of a GATA transcription factor. Proc Natl Acad Sci U S A. 2013;110:15067-72 pubmed publisher
    ..pseudomallei type III secretion system. Together, our studies using an intact host provide evidence for pathogen-mediated host immune suppression through the destruction of a host transcription factor. ..
  2. Takahashi M, Iwasaki H, Inoue H, Takahashi K. Reverse genetic analysis of the Caenorhabditis elegans 26S proteasome subunits by RNA interference. Biol Chem. 2002;383:1263-6 pubmed
    ..Ce-Rpn10 and Ce-Rpn12 are considered to compensate for the suppression of each other. ..
  3. Springer W, Hoppe T, Schmidt E, Baumeister R. A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress. Hum Mol Genet. 2005;14:3407-23 pubmed
    ..Due to high-throughput capacity of C. elegans, this model is particularly well suited to identify genetic and chemical modifiers of toxicity. ..
  4. Kamikura D, Cooper J. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Genes Dev. 2003;17:2798-811 pubmed
    ..These results suggest a model in which Ce-DAB-1 coordinates selection of receptors and cargo, including EGL-17, for transport through the secretory pathway. ..
  5. Wilson K, Qadota H, Mains P, Benian G. UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans. Mol Biol Cell. 2012;23:2623-34 pubmed publisher
    ..The level of MEI-1 protein is reduced in an unc-89 mutant, suggesting that the normal role of UNC-89 is to inhibit the CUL-3/MEL-26 complex toward MEI-1. ..