Gene Symbol: ric-3
Description: Resistance to inhibitors of cholinesterase protein 3
Alias: Resistance to inhibitors of cholinesterase protein 3
Species: Caenorhabditis elegans
Halevi S, McKay J, Palfreyman M, Yassin L, Eshel M, Jorgensen E, et al
. The C. elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors. EMBO J. 2002;21:1012-20 pubmed
..elegans DEG-3/DES-2 and of the rat alpha-7 acetylcholine receptors. Together, these data suggest that RIC-3 is specifically required for the maturation of acetylcholine receptors. ..
Ben Ami H, Yassin L, Farah H, Michaeli A, Eshel M, Treinin M. RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains. J Biol Chem. 2005;280:28053-60 pubmed
..Together our results suggest that subunit-specific interactions of RIC-3 with nAChR subunits, mediated by the transmembrane domains, are sufficient for the effects of RIC-3 on nAChR quantity and quality. ..
Safdie G, Liewald J, Kagan S, Battat E, Gottschalk A, Treinin M. RIC-3 phosphorylation enables dual regulation of excitation and inhibition of Caenorhabditis elegans muscle. Mol Biol Cell. 2016;27:2994-3003 pubmed publisher
..Moreover, regulation of inhibitory GABAA signaling by calcineurin, a calcium- and calmodulin-dependent phosphatase, enables homeostatic balancing of excitation and inhibition. ..
Nguyen M, Alfonso A, Johnson C, Rand J. Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase. Genetics. 1995;140:527-35 pubmed
..Measurements of acetylcholine levels in these mutants suggest that some of the genes are involved in presynaptic functions...
Gottschalk A, Schafer W. Visualization of integral and peripheral cell surface proteins in live Caenorhabditis elegans. J Neurosci Methods. 2006;154:68-79 pubmed
..This showed that, theoretically, any molecular interaction of sufficient affinity may be used to specifically label cell surface structures in live nematodes. ..
Cohen Ben Ami H, Biala Y, Farah H, Elishevitz E, Battat E, Treinin M. Receptor and subunit specific interactions of RIC-3 with nicotinic acetylcholine receptors. Biochemistry. 2009;48:12329-36 pubmed publisher
..Such differences may explain both the effects of RIC-3 on receptor properties and the differences in its effects on different receptors. ..
Biala Y, Liewald J, Ben Ami H, Gottschalk A, Treinin M. The conserved RIC-3 coiled-coil domain mediates receptor-specific interactions with nicotinic acetylcholine receptors. Mol Biol Cell. 2009;20:1419-27 pubmed publisher
..Thus, our results suggest that RIC-3 alternative splicing enables subtype specific regulation of nAChR maturation. ..
Shteingauz A, Cohen E, Biala Y, Treinin M. The BTB-MATH protein BATH-42 interacts with RIC-3 to regulate maturation of nicotinic acetylcholine receptors. J Cell Sci. 2009;122:807-12 pubmed publisher
..This demonstrates the importance of regulation of RIC-3 levels, and identifies a mechanism that protects cells from the deleterious effects of excess RIC-3. ..
Jospin M, Qi Y, Stawicki T, Boulin T, Schuske K, Horvitz H, et al
. A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans. PLoS Biol. 2009;7:e1000265 pubmed publisher
..These data indicate that the ACR-2 receptor is important for the coordinated excitation and inhibition of body muscles underlying sinusoidal movement. ..