rhy 1

Summary

Gene Symbol: rhy 1
Description: Regulator of hypoxia-inducible factor 1
Alias: Regulator of hypoxia-inducible factor 1
Species: Caenorhabditis elegans

Top Publications

  1. Shen C, Shao Z, Powell Coffman J. The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1. Genetics. 2006;174:1205-14 pubmed
    ..Collectively, these data support models in which RHY-1 and EGL-9 function in VHL-1-independent pathway(s) to repress HIF-1 transcriptional activity. ..
  2. Ma D, Vozdek R, Bhatla N, Horvitz H. CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans. Neuron. 2012;73:925-40 pubmed publisher
    ..These findings demonstrate that CYSL-1 acts to transduce signals from H(2)S to EGL-9 to regulate O(2)-dependent behavioral plasticity in C. elegans. ..