rde 1


Gene Symbol: rde 1
Description: hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Tabara H, Sarkissian M, Kelly W, Fleenor J, Grishok A, Timmons L, et al. The rde-1 gene, RNA interference, and transposon silencing in C. elegans. Cell. 1999;99:123-32 pubmed
    ..We discuss implications for the mechanism of RNAi and the possibility that one natural function of RNAi is transposon silencing. ..
  2. Tabara H, Yigit E, Siomi H, Mello C. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell. 2002;109:861-71 pubmed
    ..Our findings suggest a model in which RDE-4 and RDE-1 function together to detect and retain foreign dsRNA and to present this dsRNA to DCR-1 for processing. ..
  3. Yigit E, Batista P, Bei Y, Pang K, Chen C, Tolia N, et al. Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell. 2006;127:747-57 pubmed
    ..Interestingly, these AGO proteins lack key residues required for mRNA cleavage. Our findings support a two-step model for RNAi, in which functionally and structurally distinct AGOs act sequentially to direct gene silencing. ..
  4. Dudley N, Labbé J, Goldstein B. Using RNA interference to identify genes required for RNA interference. Proc Natl Acad Sci U S A. 2002;99:4191-6 pubmed
    ..The finding that genes predicted to encode proteins that associate with chromatin are involved in RNAi in C. elegans raises the possibility that chromatin may play a role in RNAi in animals, as it does in plants. ..
  5. Welker N, Habig J, Bass B. Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes. RNA. 2007;13:1090-102 pubmed
    ..However, all three data sets are enriched in genes important for innate immunity and, specifically, show increased expression of innate immunity genes. ..
  6. Steiner F, Okihara K, Hoogstrate S, Sijen T, Ketting R. RDE-1 slicer activity is required only for passenger-strand cleavage during RNAi in Caenorhabditis elegans. Nat Struct Mol Biol. 2009;16:207-11 pubmed publisher
    ..These results uncouple the role of the RDE-1 RNase H activity in small RNA maturation from its role in target-mRNA silencing in vivo. ..
  7. Iatsenko I, Sinha A, Rödelsperger C, Sommer R. New role for DCR-1/dicer in Caenorhabditis elegans innate immunity against the highly virulent bacterium Bacillus thuringiensis DB27. Infect Immun. 2013;81:3942-57 pubmed publisher
    ..Taken together, these results uncover a previously unknown role for DCR-1/Dicer in C. elegans antibacterial immunity that is largely associated with miRNA processing. ..
  8. Thivierge C, Makil N, Flamand M, Vasale J, Mello C, Wohlschlegel J, et al. Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi. Nat Struct Mol Biol. 2011;19:90-7 pubmed publisher
    ..Our results implicate tudor proteins in the recruitment of RdRP complexes to specific steps within DCR-1-dependent and DCR-1-independent endo-RNAi pathways. ..
  9. Schott D, Cureton D, Whelan S, Hunter C. An antiviral role for the RNA interference machinery in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2005;102:18420-4 pubmed
    ..Our observation that multiple genes required for RNAi are also required for resistance to vesicular stomatitis virus suggests that the RNAi machinery functions in resistance to viruses in nature. ..

More Information


  1. Gu S, Pak J, Guang S, Maniar J, Kennedy S, Fire A. Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint. Nat Genet. 2012;44:157-64 pubmed publisher
    ..These results implicate dsRNA-triggered chromatin modification in C. elegans as a programmable and locus-specific response defining a metastable state that can persist through generational boundaries. ..
  2. Fischer S, Pan Q, Breen P, Qi Y, Shi Z, Zhang C, et al. Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev. 2013;27:2678-95 pubmed publisher
    ..The conserved ARF-like small GTPase ARL-8 is required specifically for primary siRNA biogenesis or stability in the sperm-specific ALG-3/4 endogenous RNAi pathway. ..
  3. Tsai H, Chen C, Conte D, Moresco J, Chaves D, Mitani S, et al. A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi. Cell. 2015;160:407-19 pubmed publisher
    ..Together, our findings suggest a model in which RDE-8 cleaves target mRNAs to mediate silencing, while generating 3' uridylated mRNA fragments to serve as templates for the RdRP-directed amplification of the silencing signal. ..
  4. Parrish S, Fire A. Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans. RNA. 2001;7:1397-402 pubmed
    ..These results support a model in which RDE-4 is involved before or during production of siRNAs, whereas RDE-1 acts after the siRNAs have been formed. ..
  5. Qadota H, Inoue M, Hikita T, Köppen M, HARDIN J, Amano M, et al. Establishment of a tissue-specific RNAi system in C. elegans. Gene. 2007;400:166-73 pubmed
    ..Although we demonstrate tissue-specific RNAi in hypodermis and muscle, this method could be easily applied to other tissues. ..
  6. Shirayama M, Stanney W, Gu W, Seth M, Mello C. The Vasa Homolog RDE-12 engages target mRNA and multiple argonaute proteins to promote RNAi in C. elegans. Curr Biol. 2014;24:845-51 pubmed publisher
    ..Downstream of these events, RDE-12 forms an RNase-resistant (target mRNA-independent) complex with WAGO-1 and may thus have additional functions in target mRNA surveillance and silencing...