Gene Symbol: rbr-2
Description: Lysine-specific demethylase rbr-2;RB (Retinoblastoma Binding protein) Related
Alias: Lysine-specific demethylase rbr-2;RB (Retinoblastoma Binding protein) Related
Species: Caenorhabditis elegans
Lee S, Kennedy S, Tolonen A, Ruvkun G. DAF-16 target genes that control C. elegans life-span and metabolism. Science. 2003;300:644-7 pubmed
..elegans, and RNA interference inactivation of the candidates showed that many of these genes mediate distinct aspects of daf-16 function, including longevity, metabolism, and development. ..
Christensen J, Agger K, Cloos P, Pasini D, Rose S, Sennels L, et al
. RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell. 2007;128:1063-76 pubmed
..Taken together, these results suggest that H3K4me3/me2 demethylation regulated by the JARID1 family plays an important role during development. ..
Greer E, Maures T, Hauswirth A, Green E, Leeman D, Maro G, et al
. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature. 2010;466:383-7 pubmed publisher
..These results indicate that the longevity of the soma is regulated by an H3K4 methyltransferase/demethylase complex acting in the C. elegans germline. ..
Greer E, Maures T, Ucar D, Hauswirth A, Mancini E, Lim J, et al
. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature. 2011;479:365-71 pubmed publisher
..Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants. ..
Mariani L, Lussi Y, Vandamme J, Riveiro A, Salcini A. The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1. Development. 2016;143:851-63 pubmed publisher
..Thus, our results establish a precise role for epigenetic regulation in neuronal development by demonstrating a functional link between RBR-2 activity, H3K4me3 levels, the NURF complex and the expression of WSP-1. ..
Zhang H, Skop A, White J. Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos. J Cell Sci. 2008;121:155-61 pubmed publisher
..By RNAi of a weak dnc-1(ts) allele, we showed that dynactin activity was required at least for EMS spindle rotational alignment. ..
Wang S, Fisher K, Poulin G. Lineage specific trimethylation of H3 on lysine 4 during C. elegans early embryogenesis. Dev Biol. 2011;355:227-38 pubmed publisher
..In contrast, the deposition of H3K4me2 and H3K27me2/3 is not lineage restricted. Taken together, our data reveal that H3K4me3 deposition is highly regulated according to the cell lineage involved. ..
Nishibuchi G, Shibata Y, Hayakawa T, Hayakawa N, Ohtani Y, Sinmyozu K, et al
. Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex. J Biol Chem. 2014;289:28956-70 pubmed publisher
..These results suggest that KDM5A and the NuRD complex cooperatively function to control developmentally regulated genes. ..