rbg-1

Summary

Gene Symbol: rbg-1
Description: Rab3 GTPase-activating protein catalytic subunit
Alias: Rab3 GTPase-activating protein catalytic subunit
Species: Caenorhabditis elegans

Top Publications

  1. Clabecq A, Henry J, Darchen F. Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP. J Biol Chem. 2000;275:31786-91 pubmed
    ..We propose that Rab3-GAP, like Ras- and Rho-GAPs, stabilizes the transition state of Rab3 and provides a critical arginine residue to accelerate the GTPase reaction. ..
  2. Spang N, Feldmann A, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, et al. RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. Autophagy. 2014;10:2297-309 pubmed publisher
    ..In conclusion, we identify RAB3GAP1/2 as novel conserved factors of the autophagy and proteostasis network. ..