Gene Symbol: rbbp-5
Description: Retinoblastoma-binding protein homolog 5
Alias: Retinoblastoma-binding protein homolog 5
Species: Caenorhabditis elegans

Top Publications

  1. Li T, Kelly W. A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ line. PLoS Genet. 2011;7:e1001349 pubmed publisher
    ..Our results indicate that H3K4 methylation in the germline is regulated by a combination of Set1/MLL component-dependent and -independent modes of epigenetic establishment and maintenance. ..
  2. Fisher K, Southall S, Wilson J, Poulin G. Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling. Dev Biol. 2010;341:142-53 pubmed publisher
    ..Therefore, the C. elegans MLL-like complex cooperates with the NuA4/TIP60 complex to regulate the expression of a novel effector, AJM-1. ..
  3. Wang S, Fisher K, Poulin G. Lineage specific trimethylation of H3 on lysine 4 during C. elegans early embryogenesis. Dev Biol. 2011;355:227-38 pubmed publisher
    ..In contrast, the deposition of H3K4me2 and H3K27me2/3 is not lineage restricted. Taken together, our data reveal that H3K4me3 deposition is highly regulated according to the cell lineage involved. ..
  4. Vandamme J, Lettier G, Sidoli S, Di Schiavi E, N rregaard Jensen O, Salcini A. The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity. PLoS Genet. 2012;8:e1002647 pubmed publisher
    ..Taken together, these results demonstrate that UTX-1 is required for many aspects of nematode development; but, unexpectedly, this function is independent of its enzymatic activity...
  5. Zuryn S, Ahier A, Portoso M, White E, Morin M, Margueron R, et al. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Science. 2014;345:826-9 pubmed publisher
    ..Our results draw parallels between epigenetic mechanisms underlying robust Td in nature and efficient cell reprogramming in vitro. ..