Gene Symbol: rack-1
Description: Guanine nucleotide-binding protein subunit beta-2-like 1
Alias: Guanine nucleotide-binding protein subunit beta-2-like 1
Species: Caenorhabditis elegans

Top Publications

  1. Ai E, Poole D, Skop A. RACK-1 directs dynactin-dependent RAB-11 endosomal recycling during mitosis in Caenorhabditis elegans. Mol Biol Cell. 2009;20:1629-38 pubmed publisher
    ..Our findings suggest a mechanism by which RACK-1 directs the dynactin-dependent redistribution of recycling endosomes during the cell cycle, thus ensuring proper membrane trafficking events during cytokinesis. ..
  2. Marudhupandiyan S, Prithika U, Balasubramaniam B, Balamurugan K. RACK-1, a multifaceted regulator is required for C. elegans innate immunity against S. flexneri M9OT infection. Dev Comp Immunol. 2017;74:227-236 pubmed publisher
    ..The study unveils novel defense mechanisms exist for C. elegans in facilitating enhanced immunity by RACK-1 against SF infection. ..
  3. Ciche T, Sternberg P. Postembryonic RNAi in Heterorhabditis bacteriophora: a nematode insect parasite and host for insect pathogenic symbionts. BMC Dev Biol. 2007;7:101 pubmed
    ..RNA interference is an excellent reverse genetic tool to study gene function in C. elegans, and it would be useful in H. bacteriophora to exploit the H. bacteriophora genome project, currently in progress...
  4. Hebeisen M, Drysdale J, Roy R. Suppressors of the cdc-25.1(gf)-associated intestinal hyperplasia reveal important maternal roles for prp-8 and a subset of splicing factors in C. elegans. RNA. 2008;14:2618-33 pubmed publisher
    ..Our findings suggest that in addition to its important regulatory function in the C. elegans germ line, prp-8(rr40) may provide further insight into the etiology of this splicing-associated human disorder. ..
  5. Ziegler K, Kurz C, Cypowyj S, Couillault C, Pophillat M, Pujol N, et al. Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade. Cell Host Microbe. 2009;5:341-52 pubmed publisher
    ..Finally, the tribbles-like kinase nipi-3 acts upstream of PKCdelta in this antifungal immune signaling cascade. These findings greatly expand our understanding of the pathways involved in C. elegans innate immunity. ..
  6. Demarco R, Lundquist E. RACK-1 acts with Rac GTPase signaling and UNC-115/abLIM in Caenorhabditis elegans axon pathfinding and cell migration. PLoS Genet. 2010;6:e1001215 pubmed publisher
  7. Jannot G, Bajan S, Giguère N, Bouasker S, Banville I, Piquet S, et al. The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans. EMBO Rep. 2011;12:581-6 pubmed publisher
    ..Our data indicate that RACK1 can contribute to the recruitment of miRISC to the site of translation, and support a post-initiation mode of miRNA-mediated gene repression. ..
  8. Ai E, Poole D, Skop A. Long astral microtubules and RACK-1 stabilize polarity domains during maintenance phase in Caenorhabditis elegans embryos. PLoS ONE. 2011;6:e19020 pubmed publisher
    ..We found a correlation between short astral microtubules and the instability of PAR-6 and PAR-2 domains during maintenance phase. Our data support a necessary role for astral microtubules in the maintenance phase of cell polarity. ..
  9. Sieburth D, Ch ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, et al. Systematic analysis of genes required for synapse structure and function. Nature. 2005;436:510-7 pubmed
    ..Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure...

More Information


  1. Chu Y, Wang W, Chen S, Hsu Y, Yeh M, Slack F, et al. RACK-1 regulates let-7 microRNA expression and terminal cell differentiation in Caenorhabditis elegans. Cell Cycle. 2014;13:1995-2009 pubmed publisher
    ..Our results reveal that RACK-1 controls the biogenesis of a subset of miRNAs, including let-7, and in this way plays a role in the heterochronic gene pathway during C. elegans development. ..
  2. Kamaladevi A, Balamurugan K. Lactobacillus casei triggers a TLR mediated RACK-1 dependent p38 MAPK pathway in Caenorhabditis elegans to resist Klebsiella pneumoniae infection. Food Funct. 2016;7:3211-23 pubmed publisher
    ..pneumoniae infection and gene expression analysis suggested that L. casei triggered a TLR mediated RACK-1 dependent p38 MAPK pathway to increase host resistance and protect nematodes against K. pneumoniae infection. ..