Gene Symbol: rab-7
Description: RAB family
Alias: RAB family
Species: Caenorhabditis elegans

Top Publications

  1. Lackner M, Kindt R, Carroll P, Brown K, Cancilla M, Chen C, et al. Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Cancer Cell. 2005;7:325-36 pubmed
    ..These findings validate RabGGT, and by extension endosomal function, as a therapeutically relevant target for modulation of apoptosis, and enhance our understanding of the mechanism of action of FTIs. ..
  2. Poteryaev D, Fares H, Bowerman B, Spang A. Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic. EMBO J. 2007;26:301-12 pubmed
    ..We show that SAND-1 is essential for RAB-7 function at the transition from early to late endosomes, but not for RAB-7 function at lysosomes. ..
  3. Kinchen J, Doukoumetzidis K, Almendinger J, Stergiou L, Tosello Trampont A, Sifri C, et al. A pathway for phagosome maturation during engulfment of apoptotic cells. Nat Cell Biol. 2008;10:556-66 pubmed publisher
    ..Finally, we have also identified a previously undescribed biochemical complex containing Vps34, dynamin and Rab5(GDP), thus providing a mechanism for Rab5 recruitment to the nascent phagosome. ..
  4. Nicot A, Fares H, Payrastre B, Chisholm A, Labouesse M, Laporte J. The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans. Mol Biol Cell. 2006;17:3062-74 pubmed
    ..This work strongly suggests that the main function of PPK-3 is to mediate membrane retrieval from matured lysosomes through regulation of PtdIns(3,5)P2. ..
  5. Yu X, Lu N, Zhou Z. Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells. PLoS Biol. 2008;6:e61 pubmed publisher
  6. Li W, Zou W, Zhao D, Yan J, Zhu Z, Lu J, et al. C. elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5. Development. 2009;136:2445-55 pubmed publisher
  7. Grant B, Hirsh D. Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte. Mol Biol Cell. 1999;10:4311-26 pubmed
    ..We describe a new member of the low-density lipoprotein receptor superfamily, RME-2, identified in our screens for endocytosis defective mutants. We show that RME-2 is the C. elegans yolk receptor. ..
  8. Mukhopadhyay A, Pan X, Lambright D, Tissenbaum H. An endocytic pathway as a target of tubby for regulation of fat storage. EMBO Rep. 2007;8:931-8 pubmed
    ..We propose that TUB-1 controls receptor or sensory molecule degradation in neurons by regulating a RAB-7-mediated endocytic pathway. ..
  9. Skorobogata O, Rocheleau C. RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans. PLoS ONE. 2012;7:e36489 pubmed publisher
    ..Failure to downregulate EGFR signaling contributes to oncogenesis, and thus Rab7 could possess tumor suppressor activity in humans...

More Information


  1. Pant S, Sharma M, Patel K, Caplan S, Carr C, Grant B. AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling. Nat Cell Biol. 2009;11:1399-410 pubmed publisher
    ..Our results indicate that AMPH-1 and RME-1 cooperatively regulate endocytic recycling, probably through functions required for the production of cargo carriers that exit the recycling endosome for the cell surface. ..
  2. Nieto C, Almendinger J, Gysi S, Gomez Orte E, Kaech A, Hengartner M, et al. ccz-1 mediates the digestion of apoptotic corpses in C. elegans. J Cell Sci. 2010;123:2001-7 pubmed publisher
    ..We show that CCZ-1, a protein conserved from yeasts to humans, mediates the digestion of these apoptotic corpses. CCZ-1 seems to act in lysosome biogenesis and phagosome maturation by recruiting the GTPase RAB-7 over the phagosome. ..
  3. Poteryaev D, Datta S, Ackema K, Zerial M, Spang A. Identification of the switch in early-to-late endosome transition. Cell. 2010;141:497-508 pubmed publisher
    ..SAND-1/Mon1 thus acts as a switch by controlling the localization of RAB-5 and RAB-7 GEFs. ..
  4. Kinchen J, Ravichandran K. Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells. Nature. 2010;464:778-82 pubmed publisher
    ..Taken together, these data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses. ..
  5. Caruso M, Jenna S, Bouchecareilh M, Baillie D, Boismenu D, Halawani D, et al. GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48. Mol Cell Biol. 2008;28:4261-74 pubmed publisher
    ..In addition, we describe a novel signaling module involving CRP-1 and CDC-48 which may directly link the UPR to DNA remodeling and transcription control. ..
  6. Chotard L, Mishra A, Sylvain M, Tuck S, Lambright D, Rocheleau C. TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans. Mol Biol Cell. 2010;21:2285-96 pubmed publisher
    ..However, TBC-2 colocalizes primarily with RAB-7 on late endosomes and requires RAB-7 for membrane localization. Our data suggest that TBC-2 functions on late endosomes to inactivate RAB-5 during endosome maturation. ..
  7. Sato M, Sato K. Degradation of paternal mitochondria by fertilization-triggered autophagy in C. elegans embryos. Science. 2011;334:1141-4 pubmed publisher
    ..Thus, fertilization-triggered autophagy is required for selective degradation of paternal mitochondria and thereby maternal inheritance of mitochondrial DNA. ..
  8. Al Rawi S, Louvet Vallee S, Djeddi A, Sachse M, Culetto E, Hajjar C, et al. Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. Science. 2011;334:1144-7 pubmed publisher
  9. Liu K, Jian Y, Sun X, Yang C, Gao Z, Zhang Z, et al. Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. J Cell Biol. 2016;212:181-98 pubmed publisher
    ..WDR91 and WDR81 interact with Beclin1 and inhibit PI3K complex activity. These findings reveal a conserved mechanism that controls appropriate PtdIns3P levels in early-to-late endosome conversion. ..
  10. Guo P, Hu T, Zhang J, Jiang S, Wang X. Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation. Proc Natl Acad Sci U S A. 2010;107:18016-21 pubmed publisher
    ..Our data reveal the sequential action of Rab GTPases in regulating tethering, docking, and fusion of lysosomes to apoptotic cell-containing phagosomes. ..