Gene Symbol: prdx-2
Species: Caenorhabditis elegans
Isermann K, Liebau E, Roeder T, Bruchhaus I. A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans. J Mol Biol. 2004;338:745-55 pubmed
..Thus, CePrx2 may protect specifically the two types of neurons from oxidative damage or, more likely, plays a critical role in peroxide signaling in this nematode. ..
Oláhová M, Taylor S, Khazaipoul S, Wang J, Morgan B, Matsumoto K, et al
. A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance. Proc Natl Acad Sci U S A. 2008;105:19839-44 pubmed publisher
..Together the data reveal that in metazoans Prx act through multiple biochemical activities, and have tissue-specific functions in stress resistance and longevity. ..
Ha M, Soo Cho J, Baik O, Lee K, Koo H, Chung K. Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis. Proteomics. 2006;6:3339-51 pubmed
..These results suggest that the above genes may be related to cellular senescence process in determining the longevity in C. elegans and that gene inactivation renders animals susceptible to oxidative stress. ..
OlÃ¡hovÃ¡ M, Veal E. A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity. Aging Cell. 2015;14:558-68 pubmed publisher
..Together, these data suggest that loss of peroxiredoxin function may increase stress resistance by reducing insulin secretion, but that further changes in insulin ..
De Haes W, Frooninckx L, Van Assche R, Smolders A, Depuydt G, Billen J, et al
. Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc Natl Acad Sci U S A. 2014;111:E2501-9 pubmed publisher
..We show that this beneficial signal of the mitohormetic pathway is propagated by the peroxiredoxin PRDX-2...