Gene Symbol: pptr-2
Description: Serine/threonine protein phosphatase 2A regulatory subunit
Alias: Serine/threonine protein phosphatase 2A regulatory subunit
Species: Caenorhabditis elegans

Top Publications

  1. Shibata Y, Branicky R, Landaverde I, Hekimi S. Redox regulation of germline and vulval development in Caenorhabditis elegans. Science. 2003;302:1779-82 pubmed
    ..The other pathway is the oncogenic ras signaling pathway, whose action on germline as well as vulval development appears to be modulated by cytoplasmic ROS. ..
  2. Kitagawa D, Flückiger I, Polanowska J, Keller D, Reboul J, GONCZY P. PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos. Dev Cell. 2011;20:550-62 pubmed publisher
    ..These findings lead us to propose that PP2A-mediated loading of SAS-6 proteins is critical at the onset of centriole formation. ..
  3. Song M, Liu Y, Anderson D, Jahng W, O Connell K. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011;20:563-71 pubmed publisher
    ..Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation. ..
  4. Wang J, Smith J, Chen B, Schmidt H, Rasoloson D, Paix A, et al. Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans. elife. 2014;3:e04591 pubmed publisher
    ..We conclude that, despite their liquid-like behavior, P granules are non-homogeneous structures whose assembly in embryos is regulated by phosphorylation. ..