Research Topics

Genomes and Genes

Gene Symbol: pptr-1

Description: Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1

Alias: Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1

Species: Caenorhabditis elegans

Padmanabhan S, Mukhopadhyay A, Narasimhan S, Tesz G, Czech M, Tissenbaum H. A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell. 2009;136:939-51 pubmed publisher

..This study reveals a conserved role for the B56 regulatory subunit in regulating insulin signaling through AKT dephosphorylation, thereby having widespread implications in cancer and diabetes research. ..
Tischler J, Lehner B, Chen N, Fraser A. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Genome Biol. 2006;7:R69 pubmed
Wang J, Smith J, Chen B, Schmidt H, Rasoloson D, Paix A, et al. Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans. elife. 2014;3:e04591 pubmed publisher

..We conclude that, despite their liquid-like behavior, P granules are non-homogeneous structures whose assembly in embryos is regulated by phosphorylation. ..