Gene Symbol: ppk-1
Description: PIP Kinase
Alias: PIP Kinase
Species: Caenorhabditis elegans

Top Publications

  1. Xu X, Guo H, Wycuff D, Lee M. Role of phosphatidylinositol-4-phosphate 5' kinase (ppk-1) in ovulation of Caenorhabditis elegans. Exp Cell Res. 2007;313:2465-75 pubmed
    ..These results demonstrate that ppk-1 plays an essential role in IP(3) signaling and cytoskeleton organization in somatic gonad. ..
  2. Weinkove D, Bastiani M, Chessa T, Joshi D, Hauth L, Cooke F, et al. Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults. Dev Biol. 2008;313:384-97 pubmed
    ..In this study, we have characterized the PIP(2) synthesizing enzyme Type I PIP kinase (ppk-1) in Caenorhabditis elegans...
  3. Panbianco C, Weinkove D, Zanin E, Jones D, Divecha N, Gotta M, et al. A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning. Dev Cell. 2008;15:198-208 pubmed publisher
    ..Furthermore, loss of CSNK-1 leads to increased levels of PIP(2). We propose that asymmetric generation of PIP(2) by PPK-1 directs the posterior enrichment of GPR-1/2 and LIN-5, leading to posterior spindle displacement. ..
  4. Shen X, Valencia C, Gao W, Cotten S, Dong B, Huang B, et al. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Cell Calcium. 2008;43:444-56 pubmed
    ..elegans. ..
  5. Head B, Zulaika M, Ryazantsev S, van der Bliek A. A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. Mol Biol Cell. 2011;22:831-41 pubmed publisher
    ..We conclude that MOMA-1 and IMMT-1 act in the same pathway. It is likely that the observed effects on mitochondrial diameter are an indirect effect of disrupting cristae morphology. ..