Gene Symbol: ppk-1
Description: PIP Kinase
Alias: PIP Kinase
Species: Caenorhabditis elegans
Xu X, Guo H, Wycuff D, Lee M. Role of phosphatidylinositol-4-phosphate 5' kinase (ppk-1) in ovulation of Caenorhabditis elegans. Exp Cell Res. 2007;313:2465-75 pubmed
..These results demonstrate that ppk-1 plays an essential role in IP(3) signaling and cytoskeleton organization in somatic gonad. ..
Weinkove D, Bastiani M, Chessa T, Joshi D, Hauth L, Cooke F, et al
. Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults. Dev Biol. 2008;313:384-97 pubmed
..In this study, we have characterized the PIP(2) synthesizing enzyme Type I PIP kinase (ppk-1) in Caenorhabditis elegans...
Panbianco C, Weinkove D, Zanin E, Jones D, Divecha N, Gotta M, et al
. A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning. Dev Cell. 2008;15:198-208 pubmed publisher
..Furthermore, loss of CSNK-1 leads to increased levels of PIP(2). We propose that asymmetric generation of PIP(2) by PPK-1 directs the posterior enrichment of GPR-1/2 and LIN-5, leading to posterior spindle displacement. ..
Shen X, Valencia C, Gao W, Cotten S, Dong B, Huang B, et al
. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Cell Calcium. 2008;43:444-56 pubmed
Head B, Zulaika M, Ryazantsev S, van der Bliek A. A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. Mol Biol Cell. 2011;22:831-41 pubmed publisher
..We conclude that MOMA-1 and IMMT-1 act in the same pathway. It is likely that the observed effects on mitochondrial diameter are an indirect effect of disrupting cristae morphology. ..