Gene Symbol: pph-4.1
Description: Serine/threonine-protein phosphatase 4 catalytic subunit 1
Alias: Serine/threonine-protein phosphatase 4 catalytic subunit 1
Species: Caenorhabditis elegans

Top Publications

  1. Sumiyoshi E, Sugimoto A, Yamamoto M. Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans. J Cell Sci. 2002;115:1403-10 pubmed
    ..1 activity. Thus, besides promoting spindle formation, PPH-4.1 appears to play a role in either the establishment or the maintenance of chiasmata during meiotic prophase I. ..
  2. Long X, Spycher C, Han Z, Rose A, Muller F, Avruch J. TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation. Curr Biol. 2002;12:1448-61 pubmed
    ..The developmental arrest and intestinal phenotypes of CeTOR deficiency are due to an inhibition of global mRNA translation. Thus, TOR is a major upstream regulator of overall mRNA translation in C. elegans, as in yeast. ..
  3. Han X, Gomes J, Birmingham C, Pintard L, Sugimoto A, Mains P. The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo. Genetics. 2009;181:933-43 pubmed publisher
    ..The redundant regulatory pathways likely contribute in different ways to the rapid and precise post-meiotic inactivation of MEI-1 microtubule-severing activity. ..
  4. Sato Carlton A, Li X, Crawley O, Testori S, Martinez Perez E, Sugimoto A, et al. Protein phosphatase 4 promotes chromosome pairing and synapsis, and contributes to maintaining crossover competence with increasing age. PLoS Genet. 2014;10:e1004638 pubmed publisher
    ..PP4's high degree of conservation suggests it may be a universal regulator of meiotic prophase chromosome dynamics. ..