Gene Symbol: pmk-3
Description: Mitogen-activated protein kinase pmk-3;P38 Map Kinase family
Alias: Mitogen-activated protein kinase pmk-3;P38 Map Kinase family
Species: Caenorhabditis elegans

Top Publications

  1. Berman K, McKay J, Avery L, Cobb M. Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans. Mol Cell Biol Res Commun. 2001;4:337-44 pubmed
    ..PMK-1 and PMK-2 phosphorylated activating transcription factor-2 (ATF-2), indicating an activity similar to mammalian p38. When transfected into mammalian cells, these kinases, like p38, are stimulated by osmotic stresses. ..
  2. Nakata K, Abrams B, Grill B, Goncharov A, Huang X, Chisholm A, et al. Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Cell. 2005;120:407-20 pubmed
    ..DLK-1 protein levels are elevated in rpm-1 mutants. The RPM-1 RING finger can stimulate ubiquitination of DLK-1. Our data reveal a presynaptic role of a previously unknown p38 MAP kinase cascade. ..
  3. Lettre G, Kritikou E, Jaeggi M, Calixto A, Fraser A, Kamath R, et al. Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans. Cell Death Differ. 2004;11:1198-203 pubmed
    ..As apoptotic pathways are conserved, orthologues of the worm germline apoptosis genes presented here could be involved in the maintenance of genomic stability, p53 activation, and fertility in mammals. ..
  4. Munk√°csy E, Khan M, Lane R, Borror M, Park J, Bokov A, et al. DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. PLoS Genet. 2016;12:e1006133 pubmed publisher
    ..In those mitochondrial bioenergetic mutants which activate Ptbb-6::GFP, we find that dlk-1, sek-3 and pmk-3 are all required for their life extension. ..
  5. Jeong D, Lee D, Hwang S, Lee Y, Lee J, Seo M, et al. Mitochondrial chaperone HSP-60 regulates anti-bacterial immunity via p38 MAP kinase signaling. EMBO J. 2017;36:1046-1065 pubmed publisher
    ..Our study suggests that mitochondrial chaperones protect host eukaryotes from pathogenic bacteria by up-regulating cytosolic p38 MAPK signaling. ..
  6. Yan D, Wu Z, Chisholm A, Jin Y. The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell. 2009;138:1005-18 pubmed publisher
    ..Our findings identify the DLK-1 pathway as a regulator of mRNA stability in synapse formation and maintenance and also in adult axon regeneration. ..
  7. Trujillo G, Nakata K, Yan D, Maruyama I, Jin Y. A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans. Genetics. 2010;186:135-45 pubmed publisher
    ..UEV-3 can interact with the p38 MAPK PMK-3. We postulate that UEV-3 may provide additional specificity in the DLK-1 pathway by contributing to activation of PMK-3 or limiting the substrates accessible to PMK-3. ..
  8. Hoeven R, McCallum K, Cruz M, Garsin D. Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans. PLoS Pathog. 2011;7:e1002453 pubmed publisher
    ..Overall, a model is presented in which ROS generation by Ce-Duox1/BLI-3 activates a protective SKN-1 response via p38 MAPK signaling. ..
  9. Park E, Rongo C. The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons. elife. 2016;5: pubmed publisher
    ..Our findings demonstrate that p38 MAPK inhibits the hypoxia response pathway and determines how aging neurons respond to hypoxia through a novel mechanism. ..

More Information


  1. Nix P, Hisamoto N, Matsumoto K, Bastiani M. Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways. Proc Natl Acad Sci U S A. 2011;108:10738-43 pubmed publisher
    ..These two MAPKs are coregulated by the E3 ubiquitin ligase RPM-1(Phr1) via targeted degradation of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates both PMK-3(p38) and KGB-1(JNK). ..
  2. Matsunaga Y, Qadota H, Furukawa M, Choe H, Benian G. Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle. Mol Biol Cell. 2015;26:2096-111 pubmed publisher
    ..These results suggest that MAK-1 is an activator of twitchin kinase and that the p38 MAP kinase pathway may be involved in the regulation of twitchin. ..
  3. Oh C, Park S, Kim J, Moon Y. Non-mutagenic Suppression of Enterocyte Ferroportin 1 by Chemical Ribosomal Inactivation via p38 Mitogen-activated Protein Kinase (MAPK)-mediated Regulation: EVIDENCE FOR ENVIRONMENTAL HEMOCHROMATOSIS. J Biol Chem. 2016;291:19858-72 pubmed publisher
    ..This study provides molecular evidence for the modulation of iron bioavailability by ribosomal dysfunction as a potent etiological factor of non-mutagenic environmental hemochromatosis in the gut-to-blood axis. ..
  4. Chikka M, Anbalagan C, Dvorak K, Dombeck K, Prahlad V. The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective. Cell Rep. 2016;16:2399-414 pubmed publisher
    ..We propose that mitochondria are subject to constant surveillance by innate immune mechanisms. ..
  5. Hammarlund M, Nix P, Hauth L, Jorgensen E, Bastiani M. Axon regeneration requires a conserved MAP kinase pathway. Science. 2009;323:802-6 pubmed publisher
    ..We conclude that after axon injury, activation of this MAP kinase cascade is required to switch the mature neuron from an aplastic state to a state capable of growth. ..
  6. Park E, Glodowski D, Rongo C. The ubiquitin ligase RPM-1 and the p38 MAPK PMK-3 regulate AMPA receptor trafficking. PLoS ONE. 2009;4:e4284 pubmed publisher
    ..Our findings indicate a novel specialized role for RPM-1 and PMK-3/p38 MAPK in regulating the endosomal trafficking of AMPARs at central synapses. ..