Gene Symbol: plk-2
Description: Serine/threonine-protein kinase plk-2
Alias: Serine/threonine-protein kinase plk-2
Species: Caenorhabditis elegans
Chase D, Golden A, Heidecker G, Ferris D. Caenorhabditis elegans contains a third polo-like kinase gene. DNA Seq. 2000;11:327-34 pubmed
..We report here the full-length cDNA sequence of another Polo-related kinase from C. elegans. The predicted protein product has greater than 70% amino acid identity with PLK-1/Plc1, and has a highly conserved polo-box domain. ..
Nishi Y, Rogers E, Robertson S, Lin R. Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6. Development. 2008;135:687-97 pubmed publisher
..Our results provide a mechanism by which MEX-5 and MEX-6 function is temporally regulated during the crucial oocyte-to-embryo transition. ..
Labella S, Woglar A, Jantsch V, Zetka M. Polo kinases establish links between meiotic chromosomes and cytoskeletal forces essential for homolog pairing. Dev Cell. 2011;21:948-58 pubmed publisher
Nadarajan S, Lambert T, Altendorfer E, Gao J, Blower M, Waters J, et al
. Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop. elife. 2017;6: pubmed publisher
..We propose a model in which Polo-like kinases recognize crossover designation and phosphorylate SYP-4 thereby stabilizing the SC and making chromosomes less permissive for further DSB formation. ..
Harper N, Rillo R, Jover Gil S, Assaf Z, Bhalla N, Dernburg A. Pairing centers recruit a Polo-like kinase to orchestrate meiotic chromosome dynamics in C. elegans. Dev Cell. 2011;21:934-47 pubmed publisher
..This work reveals unexpected functions for the conserved family of Polo-like kinases, and advances our understanding of how meiotic processes are properly coordinated to ensure transmission of genetic information from parents to progeny...
Kim Y, Kostow N, Dernburg A. The Chromosome Axis Mediates Feedback Control of CHK-2 to Ensure Crossover Formation in C. elegans. Dev Cell. 2015;35:247-61 pubmed publisher
..These findings reveal conserved regulatory mechanisms that ensure faithful meiotic chromosome segregation in diverse species. ..