Gene Symbol: pkc-3
Description: Protein kinase C-like 3
Alias: Protein kinase C-like 3
Species: Caenorhabditis elegans

Top Publications

  1. Tabuse Y, Izumi Y, Piano F, Kemphues K, Miwa J, Ohno S. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. Development. 1998;125:3607-14 pubmed
    ..We conclude that PKC-3 plays an indispensable role in establishing embryonic polarity through interaction with PAR-3. ..
  2. Beatty A, Morton D, Kemphues K. The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo. Development. 2010;137:3995-4004 pubmed publisher
    ..LGL-1 negatively regulates the accumulation of myosin (NMY-2) on the posterior cortex, representing a possible mechanism by which LGL-1 might contribute to polarity maintenance. ..
  3. Zhang L, Wu S, Rubin C. A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly bin. J Biol Chem. 2001;276:10463-75 pubmed
    ..Thus, a PTB domain and PSDs collaborate in a novel fashion in CKA1/CKA1S to enable tethering and targeting of PKC3. Avid ligation of a PKC isoform is a previously unappreciated function for a PTB module. ..
  4. Sugiyama Y, Nishimura A, Ohno S. Symmetrically dividing cell specific division axes alteration observed in proteasome depleted C. elegans embryo. Mech Dev. 2008;125:743-55 pubmed publisher
    ..Our data suggest that the expression of RPN-2 is involved in the mechanism to suppress nuclear-centrosome rotation in symmetrically dividing cells and it may work in cooperation with PKC-3. ..
  5. Jiu Y, Hasygar K, Tang L, Liu Y, Holmberg C, B rglin T, et al. par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans. G3 (Bethesda). 2014;4:173-83 pubmed publisher
  6. Zhang L, Wu S, Rubin C. Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery. J Biol Chem. 2001;276:10476-84 pubmed
    ..Activities of DAG-stimulated PKCs and opposing protein Ser/Thr phosphatases can dynamically regulate the distribution of adapter protein between the cell periphery and cytoplasm. ..
  7. Aono S, Legouis R, Hoose W, Kemphues K. PAR-3 is required for epithelial cell polarity in the distal spermatheca of C. elegans. Development. 2004;131:2865-74 pubmed
    ..We propose that PAR-3 activity is required for the proper polarization of spermathecal cells and that defective ovulation results from defective distal spermathecal development. ..
  8. Li J, Kim H, Aceto D, Hung J, Aono S, Kemphues K. Binding to PKC-3, but not to PAR-3 or to a conventional PDZ domain ligand, is required for PAR-6 function in C. elegans. Dev Biol. 2010;340:88-98 pubmed publisher
    ..We conclude that PAR-6 binding to PKC-3, but not to PAR-3 nor to a conventional PDZ ligand, is required for PAR-6 cortical localization and function in C. elegans. ..
  9. Hao Y, Boyd L, Seydoux G. Stabilization of cell polarity by the C. elegans RING protein PAR-2. Dev Cell. 2006;10:199-208 pubmed
    ..Our findings suggest that reciprocal inhibitory interactions among PAR proteins stabilize polarity by reinforcing an initial asymmetry in PKC-3. ..

More Information


  1. Aceto D, Beers M, Kemphues K. Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans. Dev Biol. 2006;299:386-97 pubmed
    ..We conclude that the CDC-42 interaction with PAR-6 is not required for the initial establishment of asymmetry but is required for maximal cortical accumulation of PAR-6 and to maintain its asymmetry. ..
  2. Ziegler K, Kurz C, Cypowyj S, Couillault C, Pophillat M, Pujol N, et al. Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade. Cell Host Microbe. 2009;5:341-52 pubmed publisher
    ..Finally, the tribbles-like kinase nipi-3 acts upstream of PKCdelta in this antifungal immune signaling cascade. These findings greatly expand our understanding of the pathways involved in C. elegans innate immunity. ..
  3. Wu S, Staudinger J, Olson E, Rubin C. Structure, expression, and properties of an atypical protein kinase C (PKC3) from Caenorhabditis elegans. PKC3 is required for the normal progression of embryogenesis and viability of the organism. J Biol Chem. 1998;273:1130-43 pubmed
    ..A candidate anchoring/targeting protein, which binds PKC3 in vitro, has been identified. ..
  4. Galli M, Munoz J, Portegijs V, Boxem M, Grill S, Heck A, et al. aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division. Nat Cell Biol. 2011;13:1132-8 pubmed publisher
    ..This molecular interaction between polarity and spindle-positioning proteins may be used broadly in cell cleavage plane determination. ..