Genomes and Genes
Gene Symbol: pkc-3
Description: Protein kinase C-like 3
Alias: Protein kinase C-like 3
Species: Caenorhabditis elegans
- Aceto D, Beers M, Kemphues K. Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans. Dev Biol. 2006;299:386-97 pubmed..We conclude that the CDC-42 interaction with PAR-6 is not required for the initial establishment of asymmetry but is required for maximal cortical accumulation of PAR-6 and to maintain its asymmetry. ..
- Ziegler K, Kurz C, Cypowyj S, Couillault C, Pophillat M, Pujol N, et al. Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade. Cell Host Microbe. 2009;5:341-52 pubmed publisher..Finally, the tribbles-like kinase nipi-3 acts upstream of PKCdelta in this antifungal immune signaling cascade. These findings greatly expand our understanding of the pathways involved in C. elegans innate immunity. ..
- Wu S, Staudinger J, Olson E, Rubin C. Structure, expression, and properties of an atypical protein kinase C (PKC3) from Caenorhabditis elegans. PKC3 is required for the normal progression of embryogenesis and viability of the organism. J Biol Chem. 1998;273:1130-43 pubmed..A candidate anchoring/targeting protein, which binds PKC3 in vitro, has been identified. ..
- Galli M, Munoz J, Portegijs V, Boxem M, Grill S, Heck A, et al. aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division. Nat Cell Biol. 2011;13:1132-8 pubmed publisher..This molecular interaction between polarity and spindle-positioning proteins may be used broadly in cell cleavage plane determination. ..