pkc-2

Summary

Gene Symbol: pkc-2
Description: Protein kinase C;Protein kinase C-like 2
Alias: Protein kinase C;Protein kinase C-like 2
Species: Caenorhabditis elegans

Top Publications

  1. Islas Trejo A, Land M, Tcherepanova I, Freedman J, Rubin C. Structure and expression of the Caenorhabditis elegans protein kinase C2 gene. Origins and regulated expression of a family of Ca2+-activated protein kinase C isoforms. J Biol Chem. 1997;272:6629-40 pubmed
    ..Although 77- and 78-kDa PKC2 isoforms are evident throughout post-embryonic development, an 81-kDa isoform appears to be adapted for function in L1 and L2 larvae. ..
  2. Feng H, Ren M, Chen L, Rubin C. Properties, regulation, and in vivo functions of a novel protein kinase D: Caenorhabditis elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and life span. J Biol Chem. 2007;282:31273-88 pubmed
    ..The results suggest a mechanism for increased longevity and show that a PKD links DAG signals to regulation of stress responses and life span. ..
  3. Edwards M, Johnson J, Rankin K, Jenkins R, Maguire C, Morgan A, et al. PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion. J Neurosci. 2012;32:7042-51 pubmed publisher
    ..These data demonstrate that an individual DAG-dependent thermosensory behavior of an organism is effected specifically by the downstream PKC-2 phosphorylation of UNC-18 on Ser322 in AFD neurons. ..
  4. Land M, Rubin C. A Calcium- and Diacylglycerol-Stimulated Protein Kinase C (PKC), Caenorhabditis elegans PKC-2, Links Thermal Signals to Learned Behavior by Acting in Sensory Neurons and Intestinal Cells. Mol Cell Biol. 2017;37: pubmed publisher
    ..UNC-18 variants, created by mutating Ser311 or Ser322, disrupt thermotaxis and suppress PKC-2-dependent cryophilic migration. ..