Gene Symbol: pkc-1
Description: Protein kinase C;Protein kinase C-like 1B
Alias: Protein kinase C;Protein kinase C-like 1B
Species: Caenorhabditis elegans

Top Publications

  1. Feng H, Ren M, Chen L, Rubin C. Properties, regulation, and in vivo functions of a novel protein kinase D: Caenorhabditis elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and life span. J Biol Chem. 2007;282:31273-88 pubmed
    ..The results suggest a mechanism for increased longevity and show that a PKD links DAG signals to regulation of stress responses and life span. ..
  2. Shinkai Y, Yamamoto Y, Fujiwara M, Tabata T, Murayama T, Hirotsu T, et al. Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans. J Neurosci. 2011;31:3007-15 pubmed publisher
    ..These results suggest that the activity of AIA interneurons regulates the behavioral choice between the alternatives. We propose that GCY-28 and SCD-2 regulate sensory integration by modulating the activity of AIA interneurons. ..
  3. Sieburth D, Madison J, Kaplan J. PKC-1 regulates secretion of neuropeptides. Nat Neurosci. 2007;10:49-57 pubmed
    ..Similar neuropeptide secretion defects were found in mutants lacking unc-31 (encoding the protein CAPS) or unc-13 (encoding Munc13). These results suggest that PKC-1 selectively regulates DCV release from neurons...
  4. Zubovych I, Straud S, Roth M. Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans. Mol Biol Cell. 2010;21:956-69 pubmed publisher
    ..elegans. Using genetics, we show that this drug resistance requires pkc-1, the C. elegans ortholog of human PKCepsilon. ..
  5. Hyde R, Corkins M, Somers G, Hart A. PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response. Genes Brain Behav. 2011;10:286-98 pubmed publisher
    ..Thus, these results functionally link two conserved signaling pathways in adult C. elegans neurons and define distinct roles for PKC genes in vivo. ..
  6. Tabuse Y. Protein kinase C isotypes in C. elegans. J Biochem. 2002;132:519-22 pubmed
    ..C. elegans provides an excellent model system for molecular dissection of the cellular signaling pathways involving PKC. ..
  7. Tsunozaki M, Chalasani S, Bargmann C. A behavioral switch: cGMP and PKC signaling in olfactory neurons reverses odor preference in C. elegans. Neuron. 2008;59:959-71 pubmed publisher
    ..These results suggest that alternative modes of neurotransmission can couple one sensory neuron to opposite behavioral outputs. ..
  8. Adachi T, Kunitomo H, Tomioka M, Ohno H, Okochi Y, Mori I, et al. Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans. Genetics. 2010;186:1309-19 pubmed publisher
    ..A putative salt receptor GCY-22 guanylyl cyclase is required in ASER for both salt attraction and avoidance. Our results suggest that ASEL and ASER use distinct molecular mechanisms to regulate salt chemotaxis plasticity. ..
  9. Monje J, Brokate Llanos A, Pérez Jiménez M, Fidalgo M, Munoz M. pkc-1 regulates daf-2 insulin/IGF signalling-dependent control of dauer formation in Caenorhabditis elegans. Aging Cell. 2011;10:1021-31 pubmed publisher
    ..pkc-1 belongs to the novel protein kinase C (nPKC) family, members of which have been implicated in insulin resistance and diabetes in mammals, suggesting a conserved role for pkc-1 in the regulation of the insulin/IGF pathway. ..