piki-1

Summary

Gene Symbol: piki-1
Description: Phosphatidylinositol 3-kinase piki-1
Alias: Phosphatidylinositol 3-kinase piki-1
Species: Caenorhabditis elegans

Top Publications

  1. Xue Y, Fares H, Grant B, Li Z, Rose A, Clark S, et al. Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans. J Biol Chem. 2003;278:34380-6 pubmed
    ..elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34, indicates that MTMs do not simply turn off VPS34 but unexpectedly also function as positive regulators of biological processes. ..
  2. Zou W, Lu Q, Zhao D, Li W, Mapes J, Xie Y, et al. Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet. 2009;5:e1000679 pubmed publisher
    ..We propose that MTM-1 negatively regulates cell corpse engulfment through the CED-5/CED-12/CED-10 module by dephosphorylating PtdIns(3)P on the plasma membrane. ..
  3. Lu N, Shen Q, Mahoney T, Neukomm L, Wang Y, Zhou Z. Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells. PLoS Biol. 2012;10:e1001245 pubmed publisher
    ..They further shed light on how the temporally controlled reversible phosphorylation of phosphoinositides regulates the progression of multi-step cellular events...
  4. Cheng S, Wu Y, Lu Q, Yan J, Zhang H, Wang X. Autophagy genes coordinate with the class II PI/PtdIns 3-kinase PIKI-1 to regulate apoptotic cell clearance in C. elegans. Autophagy. 2013;9:2022-32 pubmed publisher
    ..Our data indicate that autophagy may coordinate with PIKI-1 to promote phagosome maturation, thus ensuring efficient clearance of apoptotic cells. ..