Gene Symbol: pig-1
Description: Maternal embryonic leucine zipper kinase
Alias: Maternal embryonic leucine zipper kinase
Species: Caenorhabditis elegans

Top Publications

  1. Cordes S, Frank C, Garriga G. The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions. Development. 2006;133:2747-56 pubmed
    ..Although MELK has been implicated in regulating the cell cycle, our data suggest that PIG-1, like other PAR-1 family members, regulates cell polarity. ..
  2. Ou G, Stuurman N, D Ambrosio M, Vale R. Polarized myosin produces unequal-size daughters during asymmetric cell division. Science. 2010;330:677-80 pubmed publisher
    ..Thus, the balance of myosin activity on the two sides of a dividing cell can govern the size and fate of the daughters. ..
  3. Denning D, Hatch V, Horvitz H. Programmed elimination of cells by caspase-independent cell extrusion in C. elegans. Nature. 2012;488:226-30 pubmed publisher
    ..Our findings reveal a mechanism for apoptotic cell elimination that is fundamentally distinct from that of canonical programmed cell death. ..
  4. Chien S, Brinkmann E, Teulière J, Garriga G. Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisions. Genetics. 2013;193:897-909 pubmed publisher
    ..Changes in cell fate may underlie many of the abnormal behaviors exhibited by cells after loss of PAR-4 or LKB1...
  5. Zahreddine H, Zhang H, Diogon M, Nagamatsu Y, Labouesse M. CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development. Curr Biol. 2010;20:322-7 pubmed publisher
    ..Our findings should help understand how hemidesmosome dynamics are regulated in vertebrate systems. ..
  6. Hirose T, Horvitz H. An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways. Nature. 2013;500:354-8 pubmed publisher
  7. Wei H, Yan B, Gagneur J, Conradt B. Caenorhabditis elegans CES-1 Snail Represses pig-1 MELK Expression To Control Asymmetric Cell Division. Genetics. 2017;206:2069-2084 pubmed publisher
    ..gt;3000 potential CES-1 Snail target genes, including pig-1, the ortholog of the oncogene maternal embryonic leucine zipper kinase (MELK)...