pgl-1

Summary

Gene Symbol: pgl-1
Description: P granule abnormality protein 1;hypothetical protein
Alias: P granule abnormality protein 1;hypothetical protein
Species: Caenorhabditis elegans
Products:     pgl-1

Top Publications

  1. Amiri A, Keiper B, Kawasaki I, Fan Y, Kohara Y, Rhoads R, et al. An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans. Development. 2001;128:3899-912 pubmed
    ..Our results suggest that C. elegans spermatogenesis requires either this specific isoform of eIF4E or an elevated level of eIF4E. ..
  2. Kawasaki I, Amiri A, Fan Y, Meyer N, Dunkelbarger S, Motohashi T, et al. The PGL family proteins associate with germ granules and function redundantly in Caenorhabditis elegans germline development. Genetics. 2004;167:645-61 pubmed
    ..Our findings demonstrate that both PGL-2 and PGL-3 are components of P granules, both interact with PGL-1, and at least PGL-3 functions redundantly with PGL-1 to ensure fertility in both sexes of C. elegans...
  3. Hanazawa M, Yonetani M, Sugimoto A. PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans. J Cell Biol. 2011;192:929-37 pubmed publisher
    ..We propose that self-association of scaffold proteins that can bind to RNPs is a general mechanism by which large RNP granules are formed. ..
  4. Voronina E, Paix A, Seydoux G. The P granule component PGL-1 promotes the localization and silencing activity of the PUF protein FBF-2 in germline stem cells. Development. 2012;139:3732-40 pubmed
    ..Our findings also support the view that P granules facilitate mRNA silencing by providing an environment in which translational repressors can encounter their mRNA targets immediately upon exit from the nucleus. ..
  5. Kawasaki I, Shim Y, Kirchner J, Kaminker J, Wood W, Strome S. PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans. Cell. 1998;94:635-45 pubmed
    ..Elimination of PGL-1 results in defective germ granules and sterility. Interestingly, PGL-1 function is required for fertility only at elevated temperatures, suggesting that germline development is inherently sensitive to temperature. ..
  6. Updike D, Hachey S, Kreher J, Strome S. P granules extend the nuclear pore complex environment in the C. elegans germ line. J Cell Biol. 2011;192:939-48 pubmed publisher
    ..Our results suggest that P granules extend the NPC environment in the germ line and provide insights into the roles of the PGL and GLH family proteins. ..
  7. Pasierbek P, Jantsch M, Melcher M, Schleiffer A, Schweizer D, Loidl J. A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction. Genes Dev. 2001;15:1349-60 pubmed
    ..The loss of yeast Rec8p from chromosome arms at meiosis I and centromeres at meiosis II coordinates the disjunction of homologs and sister chromatids at the two meiotic divisions. ..
  8. Curran S, Wu X, Riedel C, Ruvkun G. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009;459:1079-84 pubmed publisher
    ..These results indicate that the acquisition of germline characteristics by the somatic cells of C. elegans mutants with increased longevity contributes to their increased health and survival. ..
  9. Hubert A, Anderson P. The C. elegans sex determination gene laf-1 encodes a putative DEAD-box RNA helicase. Dev Biol. 2009;330:358-67 pubmed publisher
    ..We discuss potential functions of LAF-1 as a helicase and its roles in sex determination. ..

More Information

Publications15

  1. Li S, Yang P, Tian E, Zhang H. Arginine methylation modulates autophagic degradation of PGL granules in C. elegans. Mol Cell. 2013;52:421-33 pubmed publisher
    ..Our study reveals that posttranslational arginine methylation regulates the association of the cargo-receptor complex with the scaffold protein, providing a mechanism for modulating degradation efficiency in selective autophagy...
  2. Wang J, Smith J, Chen B, Schmidt H, Rasoloson D, Paix A, et al. Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans. elife. 2014;3:e04591 pubmed publisher
    ..We conclude that, despite their liquid-like behavior, P granules are non-homogeneous structures whose assembly in embryos is regulated by phosphorylation. ..
  3. Min H, Shim Y, Kawasaki I. Loss of PGL-1 and PGL-3, members of a family of constitutive germ-granule components, promotes germline apoptosis in C. elegans. J Cell Sci. 2016;129:341-53 pubmed publisher
    ..1. Our study has revealed new roles for PGL-1 and PGL-3 in the control of germline apoptosis. ..
  4. Elbaum Garfinkle S, Kim Y, Szczepaniak K, Chen C, Eckmann C, Myong S, et al. The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics. Proc Natl Acad Sci U S A. 2015;112:7189-94 pubmed publisher
  5. Andralojc K, Campbell A, Kelly A, Terrey M, Tanner P, Gans I, et al. ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans. PLoS Genet. 2017;13:e1006611 pubmed publisher
  6. Knutson A, Egelhofer T, Rechtsteiner A, Strome S. Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult Caenorhabditis elegans Germline. Genetics. 2017;206:163-178 pubmed publisher
    ..Our data identify P granules as critical modulators of the germline transcriptome and guardians of germ cell fate. ..