| pgl-1Gene Symbol: pgl-1 Description: P granule abnormality protein 1;hypothetical protein Alias: P granule abnormality protein 1;hypothetical protein Species: Caenorhabditis elegans Amiri A, Keiper B, Kawasaki I, Fan Y, Kohara Y, Rhoads R, et al. An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans. Development. 2001;128:3899-912 pubmed ..Our results suggest that C. elegans spermatogenesis requires either this specific isoform of eIF4E or an elevated level of eIF4E. .. Kawasaki I, Amiri A, Fan Y, Meyer N, Dunkelbarger S, Motohashi T, et al. The PGL family proteins associate with germ granules and function redundantly in Caenorhabditis elegans germline development. Genetics. 2004;167:645-61 pubmed ..Our findings demonstrate that both PGL-2 and PGL-3 are components of P granules, both interact with PGL-1, and at least PGL-3 functions redundantly with PGL-1 to ensure fertility in both sexes of C. elegans... Hanazawa M, Yonetani M, Sugimoto A. PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans. J Cell Biol. 2011;192:929-37 pubmed publisher ..We propose that self-association of scaffold proteins that can bind to RNPs is a general mechanism by which large RNP granules are formed. .. Voronina E, Paix A, Seydoux G. The P granule component PGL-1 promotes the localization and silencing activity of the PUF protein FBF-2 in germline stem cells. Development. 2012;139:3732-40 pubmed ..Our findings also support the view that P granules facilitate mRNA silencing by providing an environment in which translational repressors can encounter their mRNA targets immediately upon exit from the nucleus. .. Kawasaki I, Shim Y, Kirchner J, Kaminker J, Wood W, Strome S. PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans. Cell. 1998;94:635-45 pubmed ..Elimination of PGL-1 results in defective germ granules and sterility. Interestingly, PGL-1 function is required for fertility only at elevated temperatures, suggesting that germline development is inherently sensitive to temperature. .. Updike D, Hachey S, Kreher J, Strome S. P granules extend the nuclear pore complex environment in the C. elegans germ line. J Cell Biol. 2011;192:939-48 pubmed publisher ..Our results suggest that P granules extend the NPC environment in the germ line and provide insights into the roles of the PGL and GLH family proteins. .. Pasierbek P, Jantsch M, Melcher M, Schleiffer A, Schweizer D, Loidl J. A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction. Genes Dev. 2001;15:1349-60 pubmed ..The loss of yeast Rec8p from chromosome arms at meiosis I and centromeres at meiosis II coordinates the disjunction of homologs and sister chromatids at the two meiotic divisions. .. Curran S, Wu X, Riedel C, Ruvkun G. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature. 2009;459:1079-84 pubmed publisher ..These results indicate that the acquisition of germline characteristics by the somatic cells of C. elegans mutants with increased longevity contributes to their increased health and survival. .. Hubert A, Anderson P. The C. elegans sex determination gene laf-1 encodes a putative DEAD-box RNA helicase. Dev Biol. 2009;330:358-67 pubmed publisher ..We discuss potential functions of LAF-1 as a helicase and its roles in sex determination. ..
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