Gene Symbol: pdr-1
Description: E3 ubiquitin-protein ligase parkin;Parkinson's Disease Related
Alias: E3 ubiquitin-protein ligase parkin;Parkinson's Disease Related
Species: Caenorhabditis elegans
Springer W, Hoppe T, Schmidt E, Baumeister R. A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress. Hum Mol Genet. 2005;14:3407-23 pubmed
..Due to high-throughput capacity of C. elegans, this model is particularly well suited to identify genetic and chemical modifiers of toxicity. ..
Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, et al
. Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem. 2005;280:42655-42668 pubmed publisher
..These results show that diverse PD-related genetic modifications disrupt the mitochondrial function in C. elegans, and they raise the possibility that mitochondrial disruption is a pathway shared in common by many types of familial PD. ..
Bornhorst J, Chakraborty S, Meyer S, Lohren H, Brinkhaus S, Knight A, et al
. The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of ?-synuclein in C. elegans. Metallomics. 2014;6:476-90 pubmed publisher
Valenci I, Yonai L, Bar Yaacov D, Mishmar D, Ben Zvi A. Parkin modulates heteroplasmy of truncated mtDNA in Caenorhabditis elegans. Mitochondrion. 2015;20:64-70 pubmed publisher
..Therefore, our findings show that the role of Parkin in the modulation of heteroplasmy is conserved between human and worm and raise the interesting possibility that mitophagy modulates the striking lack of heteroplasmy in C. elegans. ..
Chakraborty S, Chen P, Bornhorst J, Schwerdtle T, Schumacher F, Kleuser B, et al
. Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans. Metallomics. 2015;7:847-56 pubmed publisher
..These changes suggest a novel role of pdr-1 in modulating Mn export through altered transporter expression, and provides further support of metal dyshomeostasis as a component of Parkinsonism pathophysiology. ..
Cabello J, Sämann J, Gomez Orte E, Erazo T, Coppa A, Pujol A, et al
. PDR-1/hParkin negatively regulates the phagocytosis of apoptotic cell corpses in Caenorhabditis elegans. Cell Death Dis. 2014;5:e1120 pubmed publisher
..Our genetic and biochemical studies indicate that PDR-1 inhibits apoptotic cell engulfment and DTC migration by ubiquitylating CED-10 for degradation. ..
Palikaras K, Lionaki E, Tavernarakis N. Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature. 2015;521:525-8 pubmed publisher
..Uncoupling of these two processes during ageing contributes to overproliferation of damaged mitochondria and decline of cellular function. ..
Martinez B, Kim H, Ray A, Caldwell G, Caldwell K. A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans. Cell Death Dis. 2015;6:e1908 pubmed publisher
..These studies mechanistically advance our understanding of a putative environmental contributor to neurodegeneration and factors influencing in vivo neurotoxicity. ..