Gene Symbol: pde-1
Description: Phosphodiesterase;Probable 3',5'-cyclic phosphodiesterase pde-1
Alias: Phosphodiesterase;Probable 3',5'-cyclic phosphodiesterase pde-1
Species: Caenorhabditis elegans
Liu J, Ward A, Gao J, Dong Y, Nishio N, Inada H, et al
. C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog. Nat Neurosci. 2010;13:715-22 pubmed publisher
..Our results identify a phototransduction cascade in C. elegans and implicate the function of a 'taste receptor' in phototransduction. ..
Shen X, Valencia C, Gao W, Cotten S, Dong B, Huang B, et al
. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Cell Calcium. 2008;43:444-56 pubmed
Fievet B, Rodriguez J, Naganathan S, Lee C, Zeiser E, Ishidate T, et al
. Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy. Nat Cell Biol. 2013;15:103-12 pubmed publisher
..Similar systematic genetic interaction screens for other biological processes will help uncover the inventory of relevant genes and their patterns of interactions. ..
Murayama T, Takayama J, Fujiwara M, Maruyama I. Environmental alkalinity sensing mediated by the transmembrane guanylyl cyclase GCY-14 in C. elegans. Curr Biol. 2013;23:1007-12 pubmed publisher
..These results argue that in addition to ion channels and GPCRs, RGCs also play a role in pH sensation in neurons...
Couto A, Oda S, Nikolaev V, Soltesz Z, de Bono M. In vivo genetic dissection of O2-evoked cGMP dynamics in a Caenorhabditis elegans gas sensor. Proc Natl Acad Sci U S A. 2013;110:E3301-10 pubmed publisher
..This variability may reflect stochastic differences in expression of cGMP signaling components. Our work provides in vivo insights into the architecture of neuronal cGMP signaling. ..
Singhvi A, Liu B, Friedman C, Fong J, Lu Y, Huang X, et al
. A Glial K/Cl Transporter Controls Neuronal Receptive Ending Shape by Chloride Inhibition of an rGC. Cell. 2016;165:936-48 pubmed publisher
..Components of this pathway are broadly expressed throughout the nervous system, suggesting that ionic regulation of the NRE microenvironment may be a conserved mechanism by which glia control neuron shape and function. ..
Beckert U, Aw W, Burhenne H, Försterling L, Kaever V, Timmons L, et al
. The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected]. PLoS ONE. 2013;8:e72569 pubmed publisher
..elegans using highly specific HPLC-coupled tandem mass-spectrometry and behavioral assays. Here, we show that the relation between cGMP and survival is more complex than previously appreciated. ..