Gene Symbol: pck-1
Description: Phosphoenolypyruvate CarboxyKinase
Alias: Phosphoenolypyruvate CarboxyKinase
Species: Caenorhabditis elegans

Top Publications

  1. Yuan Y, Kadiyala C, Ching T, Hakimi P, Saha S, Xu H, et al. Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. J Biol Chem. 2012;287:31414-26 pubmed publisher
    ..We conclude that an increase, not a decrease in fuel consumption, via an accelerated oxidation of fuels in the TCA cycle is involved in life span regulation; this mechanism may be conserved across phylogeny. ..
  2. Yuan Y, Hakimi P, Kao C, Kao A, Liu R, Janocha A, et al. Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans. J Biol Chem. 2016;291:1307-19 pubmed publisher
    ..Thus, a programmed metabolic event involving PEPCK-C and PK is a determinant of aging that can be modified to modulate aging. ..