Research TopicsGenomes and Genes | par-1SummaryGene Symbol: par-1 Description: Serine/threonine-protein kinase par-1;hypothetical protein Alias: Serine/threonine-protein kinase par-1;hypothetical protein Species: Caenorhabditis elegans Products: par-1 Top Publications
| Scientific ExpertsLocale
|
More Information
Publications
- Panbianco C, Weinkove D, Zanin E, Jones D, Divecha N, Gotta M, et al. A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning. Dev Cell. 2008;15:198-208 pubmed publisher..Furthermore, loss of CSNK-1 leads to increased levels of PIP(2). We propose that asymmetric generation of PIP(2) by PPK-1 directs the posterior enrichment of GPR-1/2 and LIN-5, leading to posterior spindle displacement. ..
- Boyd L, Guo S, Levitan D, Stinchcomb D, Kemphues K. PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos. Development. 1996;122:3075-84 pubmed..We also find that, although par-2 activity is not required for posterior localization of P granules at the one-cell stage, it is required for proper cortical association of P granules in P1. ..
- Guo S, Kemphues K. A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans. Nature. 1996;382:455-8 pubmed..We therefore conclude the NMY-2 is required for establishing cellular polarity in C. elegans embryos. ..
- Chien S, Brinkmann E, Teulière J, Garriga G. Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisions. Genetics. 2013;193:897-909 pubmed publisher..Changes in cell fate may underlie many of the abnormal behaviors exhibited by cells after loss of PAR-4 or LKB1...
- Benton R, Palacios I, St Johnston D. Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation. Dev Cell. 2002;3:659-71 pubmed..The C. elegans 14-3-3 protein, PAR-5, is also required for A-P polarization, suggesting that this is a conserved mechanism by which PAR-1 establishes cellular asymmetries. ..
- Tassan J, Le Goff X. An overview of the KIN1/PAR-1/MARK kinase family. Biol Cell. 2004;96:193-9 pubmed..Some common modes of action can be deciphered for this protein kinase family. ..
- Huang N, Mootz D, Walhout A, Vidal M, Hunter C. MEX-3 interacting proteins link cell polarity to asymmetric gene expression in Caenorhabditis elegans. Development. 2002;129:747-59 pubmed..We propose that MEX-6 and SPN-4 act with MEX-3 to translate the temporal and spatial information provided by the early acting par genes into the asymmetric expression of the cell fate determinant PAL-1. ..
- Tenlen J, Molk J, London N, Page B, Priess J. MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation. Development. 2008;135:3665-75 pubmed publisher..PAR-1 and PAR-4 kinase activities are required for the phosphorylation of S458, providing a link between PAR polarity proteins and the cytoplasmic asymmetry of MEX-5. ..
- Morton D, Shakes D, Nugent S, Dichoso D, Wang W, Golden A, et al. The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo. Dev Biol. 2002;241:47-58 pubmed..Our analysis indicates that the par-5 14-3-3 gene plays a crucial role in the early events leading to polarization of the C. elegans zygote. ..
- Motegi F, Zonies S, Hao Y, Cuenca A, Griffin E, Seydoux G. Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes. Nat Cell Biol. 2011;13:1361-7 pubmed publisher..Our findings illustrate how microtubules, independently of actin dynamics, stimulate the self-organization of PAR proteins by providing local protection against a global barrier imposed by aPKC...
- Benkemoun L, Descoteaux C, Chartier N, Pintard L, Labbé J. PAR-4/LKB1 regulates DNA replication during asynchronous division of the early C. elegans embryo. J Cell Biol. 2014;205:447-55 pubmed publisher..elegans early embryonic development and further provide a novel mechanism by which PAR proteins control cell cycle progression during asynchronous cell division. ..
- Wu J, Espiritu E, Rose L. The 14-3-3 protein PAR-5 regulates the asymmetric localization of the LET-99 spindle positioning protein. Dev Biol. 2016;412:288-297 pubmed publisher..Together the results indicate that PAR-5 acts in a mechanism with PAR-1 to regulate LET-99 cortical localization. ..
- Butkevich E, Härtig W, Nikolov M, Erck C, Grosche J, Urlaub H, et al. Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking. Sci Rep. 2016;6:26965 pubmed publisher..Our findings suggest that perturbed FEZ1-mediated synaptic delivery of proteins arising from abnormal signalling potentially contributes to the process of neurodegeneration. ..