Gene Symbol: pak-1
Description: Serine/threonine-protein kinase pak-1
Alias: Serine/threonine-protein kinase pak-1
Species: Caenorhabditis elegans
Chen W, Chen S, Yap S, Lim L. The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation. J Biol Chem. 1996;271:26362-8 pubmed
..Interestingly, CeRac1 and CDC42Ce are found at the same location, which might point to their common involvement in hypodermal cell fusion, a crucial morphogenetic event for nematode development. ..
Iino Y, Yamamoto M. Expression pattern of the C. elegans P21-activated protein kinase, CePAK. Biochem Biophys Res Commun. 1998;245:177-84 pubmed
..The CePAK::GFP fusion protein was preferentially localized to the cell surface in pharyngeal muscles. ..
Quinn C, Pfeil D, Wadsworth W. CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin. Curr Biol. 2008;18:808-13 pubmed publisher
..We propose that the interaction between activated CED-10/Rac1 and MIG-10/lamellipodin triggers local cytoskeletal assembly and polarizes outgrowth activity in response to UNC-6/netrin. ..
Lucanic M, Cheng H. A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans. PLoS Genet. 2008;4:e1000269 pubmed publisher
Zahreddine H, Zhang H, Diogon M, Nagamatsu Y, Labouesse M. CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development. Curr Biol. 2010;20:322-7 pubmed publisher
..Our findings should help understand how hemidesmosome dynamics are regulated in vertebrate systems. ..
Zhang H, Landmann F, Zahreddine H, Rodriguez D, Koch M, Labouesse M. A tension-induced mechanotransduction pathway promotes epithelial morphogenesis. Nature. 2011;471:99-103 pubmed publisher
..We suggest that similar pathways could promote epithelial morphogenesis or wound healing in other organisms in which epithelial cells adhere to tension-generating contractile cells...
Yanase S, Luo Y, Maruta H. PAK1-deficiency/down-regulation reduces brood size, activates HSP16.2 gene and extends lifespan in Caenorhabditis elegans. Drug Discov Ther. 2013;7:29-35 pubmed
..2 gene activation) of this worm could be used as the first indicator of extended lifespan for a quick in vivo screening for PAK1-blockers...
Kennedy L, Pham S, Grishok A. Nonautonomous regulation of neuronal migration by insulin signaling, DAF-16/FOXO, and PAK-1. Cell Rep. 2013;4:996-1009 pubmed publisher
..Because a FOXO-Pak1 pathway was recently shown to regulate mammalian neuronal polarity, our findings indicate that the roles of FOXO and Pak1 in neuronal migration are most likely conserved from C. elegans to higher organisms. ..
Gally C, Wissler F, Zahreddine H, Quintin S, Landmann F, Labouesse M. Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles. Development. 2009;136:3109-19 pubmed publisher
..Moreover, we suggest that ROCK and PAK regulate at least one other target essential for elongation, in addition to MLC-4. ..