pac-1

Summary

Gene Symbol: pac-1
Description: GTPase-activating protein pac-1;hypothetical protein
Alias: GTPase-activating protein pac-1;hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Chen W, Blanc J, Lim L. Characterization of a promiscuous GTPase-activating protein that has a Bcr-related domain from Caenorhabditis elegans. J Biol Chem. 1994;269:820-3 pubmed
    ..Together with the presence of the pleckstrin homology motif, our finding suggests a central and integrative role for CeGAP in a signaling pathway common to Ras and related proteins. ..
  2. Anderson D, Gill J, Cinalli R, Nance J. Polarization of the C. elegans embryo by RhoGAP-mediated exclusion of PAR-6 from cell contacts. Science. 2008;320:1771-4 pubmed publisher
    ..Thus, PAC-1 provides a dynamic molecular link between cell contacts and PAR proteins that polarizes embryos radially. ..
  3. Klompstra D, Anderson D, Yeh J, Zilberman Y, Nance J. An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity. Nat Cell Biol. 2015;17:726-35 pubmed publisher
    ..Our findings identify an E-cadherin-mediated pathway that translates cell contacts into cortical polarity by directly recruiting a symmetry-breaking factor to the adjacent cortex. ..