pab-2

Summary

Gene Symbol: pab-2
Description: Polyadenylate-binding protein
Alias: Polyadenylate-binding protein
Species: Caenorhabditis elegans

Top Publications

  1. Tischler J, Lehner B, Chen N, Fraser A. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Genome Biol. 2006;7:R69 pubmed
  2. Nousch M, Yeroslaviz A, Habermann B, Eckmann C. The cytoplasmic poly(A) polymerases GLD-2 and GLD-4 promote general gene expression via distinct mechanisms. Nucleic Acids Res. 2014;42:11622-33 pubmed publisher
    ..Our combined data show that distinct cytoPAPs employ different RNA-regulatory mechanisms to promote gene expression, offering new insights into translational activation of mRNAs. ..
  3. Flamand M, Wu E, Vashisht A, Jannot G, Keiper B, Simard M, et al. Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans. Nucleic Acids Res. 2016;44:5924-35 pubmed publisher
    ..Our results refine the roles of PABPs in miRNA-mediated silencing and support a model wherein they enable miRNA-binding sites by looping the 3'UTR poly(A) tail to the bound miRISC and deadenylase. ..