paa-1

Summary

Gene Symbol: paa-1
Description: Probable serine/threonine-protein phosphatase PP2A regulatory subunit
Alias: Probable serine/threonine-protein phosphatase PP2A regulatory subunit
Species: Caenorhabditis elegans

Top Publications

  1. Schlaitz A, Srayko M, Dammermann A, Quintin S, Wielsch N, MacLeod I, et al. The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Cell. 2007;128:115-27 pubmed
    ..By regulating a subset of PP2A functions at the centrosome, the RSA complex could therefore provide a means of coordinating microtubule outgrowth from centrosomes and kinetochore microtubule stability during mitotic spindle assembly. ..
  2. Song M, Liu Y, Anderson D, Jahng W, O Connell K. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011;20:563-71 pubmed publisher
    ..Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation. ..
  3. Anders K, Grimson A, Anderson P. SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. EMBO J. 2003;22:641-50 pubmed
    ..Our results suggest that PP2A is the SMG-2 phosphatase, and the role of SMG-5 is to direct PP2A to its SMG-2 substrate. We discuss cycles of SMG-2 phosphorylation and their roles in NMD. ..
  4. Lange K, Heinrichs J, Cheung K, Srayko M. Suppressor mutations identify amino acids in PAA-1/PR65 that facilitate regulatory RSA-1/B? subunit targeting of PP2A to centrosomes in C. elegans. Biol Open. 2013;2:88-94 pubmed publisher
    ..In the context of previously published results, these data propose a mechanism of how different PP2A B-regulatory subunit families can bind the same holoenzyme in a mutually exclusive manner, to perform specific tasks in vivo. ..